Background Meropenem exhibits time-dependent antimicrobial activity and prolonged
infusion (PI)(extended infusion or continuous infusion, EI or CI) of meropenem can better …

Introduction: The pharmacokinetic/pharmacodynamic index determining β-lactam activity is
the percentage of the dosing interval (% T) during which their free serum concentration …

Optimization of antimicrobial dosing in accordance with pharmacokinetics/
pharmacodynamics targets can improve survival and clinical cure. Dosing regimens for …

Abstract Background Several population pharmacokinetic (PopPK) models for meropenem
dosing in ICU patients are available. It is not known to what extent these models can predict …

Purpose This study aimed to develop a population pharmacokinetic (PPK) model for
meropenem to optimize dosing regimens for critically ill patients with pulmonary infection …

Currently there are no pharmacokinetic (PK) data to guide antibiotic dosing in critically ill
Australian Indigenous patients with severe sepsis. This study aimed to determine whether …

Background: Sporadic studies in antimicrobial therapy have evaluated the effects of infusion
rates on therapeutic and economic outcomes, and new findings may challenge the regular …

Aims Beta‐lactam dose optimization in critical care is a current priority. We aimed to review
the pharmacokinetics (PK) of three commonly used beta‐lactams (amoxicillin±clavulanate …

Background This study aimed to select piperacillin/tazobactam (TZP) infusion mode guided
by Sequential Organ Failure Assessment (SOFA) score in cancer patients with hospital …

Background: High doses of ampicillin are often used to achieve therapeutic drug
concentrations in infants. A paradoxical antibiotic effect, often called the Eagle effect, occurs …