The neurovascular unit (NVU) is composed of vascular cells, glial cells, and neurons. As a
fundamental functional module in the central nervous system, the NVU maintains …

The percutaneous device dilemma describes etiological factors, centered around the
disrupted epithelial tissue surrounding non-remodelable devices, that contribute to rampant …

Laminin, an extracellular matrix protein, is widely expressed in the central nervous system
(CNS). By interacting with integrin and non‐integrin receptors, laminin exerts a large variety …

Vascular comorbidities have a deleterious impact on multiple sclerosis clinical outcomes but
it is unclear whether this is mediated by an excess of extracranial vascular disease (ie …

Blood vessels in the central nervous system (CNS) are unique in having high electrical
resistance and low permeability, which creates a selective barrier protecting sensitive neural …

Laminin, a major component of the basal lamina (BL), is a heterotrimeric protein with many
isoforms. In the CNS, laminin is expressed by almost all cell types, yet different cells …

The integrin family is involved in various biological functions, including cell proliferation,
differentiation and migration, and also in the pathogenesis of disease. Integrins are …

The blood-brain barrier is a unique property of central nervous system blood vessels that
protects sensitive central nervous system cells from potentially harmful blood components …

Laminin, a non-collagenous glycoprotein present in the brain extracellular matrix, helps to
maintain blood–brain barrier (BBB) integrity and regulation. Neuroinflammation can …

Blood-brain barrier disruption is one of the hallmarks of multiple sclerosis. Mesenchymal
stem cells showed great potential for the multiple sclerosis therapy. However, the effect of …