Glutathione S-transferase P is abundantly expressed in some mammalian tissues,
particularly those associated with malignancies. While the enzyme can catalyze thioether …

Numerous studies have shown that oxidative stress resulting from an imbalance between
the production of free radicals and their neutralization by antioxidant enzymes is one of the …

Purpose Cisplatin, a cornerstone of combination chemotherapy in the treatment of testicular
cancer, induces hearing impairment with considerable interindividual variations. These …

The authors performed a systematic review and meta-analysis to determine the effect of
polymorphisms in genes encoding glutathione S-transferases (GST s), phase II isoenzymes …

Background To assess the impact of polymorphisms in Glutathione S-transferase (GST)-P1,-
M1, and-T1 on self-reported chemotherapy-induced long-term toxicities in testicular cancer …

Purpose: Epigenetic changes play a role and cooperate with genetic alterations in the
pathogenesis of myelodysplastic syndromes (MDS). We conducted a phase II multicenter …

A wide interindividual variability in survival after cancer treatment is observed. This is
attributable to many factors, including tumour and patient related factors. Genetic …

Glutathione S-transferases (GSTs) are polymorphic enzymes that catalyze the glutathione
conjugation of alkylating agents, platinum compounds, and free radicals formed by radiation …

Cyclophosphamide is a cornerstone in the treatment of many pediatric and adult
malignancies, as well as in the treatment of refractory autoimmune conditions. Genetic …

Hodgkin lymphoma (HL) is among the neoplastic diseases that has the best long-term
outcome after cytotoxic treatment. Cure rates approach 80–90%; however, 15–20% of …