Obesity is a critical risk factor for the development of type 2 diabetes (T2D), and its
prevalence is rising worldwide. White adipose tissue (WAT) has a crucial role in regulating …

Aim Over the last decades, the shift in age distribution towards older ages and the
progressive ageing which has occurred in most populations have been paralleled by a …

Epigenetic dysregulation has emerged as a recurring mechanism in the etiology of
neurodevelopmental disorders. Two such disorders, CHARGE and Kabuki syndromes …

The transcription factor HOXA5, from the HOX gene family, has long been studied due to its
critical role in physiological activities in normal cells, such as organ development and body …

Folic acid (FA) supplementation may protect from obesity and insulin resistance, the effects
and mechanism of FA on chronic high-fat-diet-induced obesity-related metabolic disorders …

Dysregulation of circulating lipids is a central element for the metabolic syndrome. However,
it is not well established whether human subcutaneous adipose tissue is affected by or affect …

The global prevalence of metabolic disorders, such as obesity, diabetes and fatty liver
disease, is dramatically increasing. Both genetic and environmental factors are well-known …

A healthy diet improves life expectancy and helps to prevent common chronic diseases such
as type 2 diabetes (T2D) and obesity. The mechanisms driving these effects are not fully …

For the past several decades, the prevalence of obesity and type 2 diabetes (T2D) has
continued to rise on a global level. The risk contributing to this pandemic implicates both …

Aims/hypothesis Subcutaneous adipocyte hypertrophy is associated with insulin resistance
and increased risk of type 2 diabetes, and predicts its future development independent of …