Neutrophils are the most abundant myeloid cells in human blood and are emerging as
important regulators of cancer. However, their functional importance has often been …

Mast cells are immune cells of the haematopoietic lineage that are now thought to have
multifaceted functions during homeostasis and in various disease states. Furthermore, while …

The stromal compartment of the tumor microenvironment consists of a heterogeneous set of
tissue-resident and tumor-infiltrating cells, which are profoundly moulded by cancer cells. An …

Mast cells have existed long before the development of adaptive immunity, although they
have been given different names. Thus, in the marine urochordate Styela plicata, they have …

Certain transcription factors have vital roles in lineage development, including specification
of cell types and control of differentiation. Microphthalmia-associated transcription factor …

Mast cells and their mediators have been implicated in the pathogenesis of asthma and
allergy for decades. Allergic asthma is a complex chronic lung disease in which several …

Neutrophils are short-lived cells that play important roles in both health and disease.
Neutrophils and monocytes originate from the granulocyte monocyte progenitor (GMP) in …

Mast cells are (in) famous for their role in allergic diseases, but the physiological and
pathophysiological roles of this ingenious cell are still not fully understood. Mast cells are …

Mast cells in tissues are developed from mast cell progenitors emerging from the bone
marrow in a process highly regulated by transcription factors. Through the advancement of …

Cancer cells have an increased demand for energy sources to support accelerated rates of
growth. When nutrients become limiting, cancer cells may switch to nonconventional energy …