Complex Inhibitory Activity of Pentacyclic Triterpenoids against Cutaneous Melanoma In Vitro and In Vivo: A Literature Review and Reconstruction of Their Melanoma …

AD Moralev, MA Zenkova… - ACS Pharmacology & …, 2024 - ACS Publications
Pentacyclic triterpenoids (PTs) are a class of plant metabolites with a wide range of
pharmacological activities, including strong antitumor potential against skin malignancies …

Synthesis and preliminary cytotoxicity evaluation of water soluble pentacyclic triterpenoid phosphonates

J Lugiņina, V Kroškins, R Lācis, E Fedorovska… - Scientific Reports, 2024 - nature.com
Synthesis, solubility and cytotoxicity evaluation of anionic phosphonates derived from
betulin, betulinic acid, oleanolic acid and ursolic acid is reported. Phosphonate moieties …

Enhanced Cytotoxicity and Antimelanoma Activity of Novel Semisynthetic Derivatives of Betulinic Acid with Indole Conjugation

A Lombrea, CG Watz, L Bora, CA Dehelean… - Plants, 2023 - mdpi.com
The prevalence and severity of skin cancer, specifically malignant melanoma, among
Caucasians remains a significant concern. Natural compounds from plants have long been …

[HTML][HTML] Assessment of the Lipophilicity of Indole Derivatives of Betulin and Their Toxicity in a Zebrafish Model

Z Rzepka, K Bober-Majnusz, JM Hermanowicz… - …, 2024 - pmc.ncbi.nlm.nih.gov
There are scientific studies indicating that the attachment of an indole moiety to the
triterpene scaffold can lead to increased anticancer potential. Lipophilicity is one of the …

Antiviral opportunities of Mannich bases derived from triterpenic N‐propargylated indoles

A Petrova, E Tretyakova… - Chemical Biology & …, 2024 - Wiley Online Library
Oleanolic and glycyrrhetic acids alkyne derivatives were synthesized as a result of
propargylation of the indole NH‐group condensed with the triterpene A‐ring, the following …

含膦酸酯肽的蛇床子素衍生物的合成与抗菌活性

杨家强, 周绪容, 陈阳密, 佘慧娴 - 有机化学 - sioc-journal.cn
摘要在前期研究基础上, 对具有潜在抗菌活性的蛇床子素衍生物进行结构优化, 设计合成了21
个含膦酸酯肽的新型衍生物, 经1H NMR, 13C NMR 和元素分析确证其结构 …

Synthesis and Antibacterial Activities of Osthole Derivatives Containing Phosphonateptide Fragment

J Yang, X Zhou, Y Chen, H She - Chinese Journal of Organic Chemistry - sioc-journal.cn
Based on previous research, the structures of osthole derivatives with potential antibacterial
activities were optimized. Twenty-one novel derivatives containing phosphonateptide were …