Colorectal cancer (CRC) is a heterogeneous disease, including at least three major forms:
hereditary, sporadic and colitis-associated CRC. A large body of evidence indicates that …

Colorectal cancer is the third common cancer in this world, accounting for more than 1
million cases each year. However, detailed etiology and mechanism of colorectal cancer …

Abstract Elevated tumor cyclooxygenase-2 (COX-2) expression is associated with tumor
invasion, metastasis, and poor prognosis in non–small cell lung cancer (NSCLC). Here, we …

It is now well established that the immune system can control neoplastic development and
growth in a process termed immunosurveillance. A link between host immunosurveillance …

The limitations of current chemotherapeutic drugs are still a major issue in cancer treatment.
Thus, targeted multimodal therapeutic approaches need to be strategically developed to …

Overexpression and enhanced activation of the epidermal growth factor receptor (EGFR) is
frequently observed in human carcinomas. Inhibitors of EGFR signaling have shown clinical …

The discovery of epidermal growth factor receptor tyrosine kinase inhibitor (EGFR TKI) has
led to unprecedented clinical response in a subset of lung cancer patients carrying the …

Background The resistance to PD-1/PD-L1 inhibitors for the treatment of melanoma have
prompted investigators to implement novel clinical trials which combine immunotherapy with …

[Frontiers in Bioscience 13, 1857-1865, January 1, 2008] 1857 Crosstalk between G-protein-coupled
receptors and Epidermal growt Page 1 [Frontiers in Bioscience 13, 1857-1865, January 1 …

Lung carcinogenesis is a complex process involving the acquisition of genetic mutations that
confer cancer development and the malignant phenotype, and is critically linked to …