We have conducted a detailed transcriptomic, proteomic and phosphoproteomic analysis of
CDK8 and its paralog CDK19, alternative enzymatic components of the kinase module …

Breast cancers (BrCas) that overexpress oncogenic tyrosine kinase receptor HER2 are
treated with HER2-targeting antibodies (such as trastuzumab) or small-molecule kinase …

Mediator kinases CDK19 and CDK8, pleiotropic regulators of transcriptional reprogramming,
are differentially regulated by androgen signaling, but both kinases are upregulated in …

Prostate cancer is a prevalent malignancy among men globally, and androgen deprivation
therapy is the conventional first-line treatment for metastatic prostate cancer. While …

CDK8 is an important member of the cyclin-dependent kinase family associated with
transcription and acts as a key “molecular switch” in the Mediator complex. CDK8 regulates …

Cyclin-dependent protein kinase 8 (CDK8) plays important roles in regulating fibrotic growth
factors and inflammatory signaling pathways. Long-term chronic inflammation of the lungs …

Triple-negative breast cancers (TNBC) are treated primarily by chemotherapy and lack
clinically validated therapeutic targets. In particular, inhibitors of the PI3K/AKT/mTOR …

A novel protocol for the construction of functionalized 1 H-pyrrolo [3, 4-c] quinoline-1, 3 (2 H)-
diones (PQLs, 3) from N-phenylglycines and maleimides was developed. The cascade …

Macrocyclic drugs can address an increasing range of molecular targets but enabling
central nervous system (CNS) access to these drugs has been viewed as an intractable …

Latent HIV-1 provirus represents the barrier toward a cure for infection and is dependent
upon the host RNA Polymerase (Pol) II machinery for reemergence. Here, we find that …