The Human Immunodeficiency Virus (HIV) is one of the most threatening viral agents. This
virus infects approximately 33 million people, many of whom are unaware of their status …

We review mathematical modeling and related statistical issues of HIV dynamics primarily in
response to antiretroviral drug therapy in this article. We start from a basic model of virus …

New stochastic models are developed for the dynamics of a viral infection and an immune
response during the early stages of infection. The stochastic models are derived based on …

Viral production from infected cells can occur continuously or in a burst that generally kills
the cell. For HIV infection, both modes of production have been suggested. Standard viral …

Mammalian gene expression patterns, and their variability across populations of cells, are
regulated by factors specific to each gene in concert with its surrounding cellular and …

Antiviral pre-exposure prophylaxis (PrEP) through daily drug administration can protect
healthy individuals from HIV-1 infection. While PrEP was recently approved by the FDA, the …

Characterizing infectivity as a function of pathogen dose is integral to microbial risk
assessment. Dose-response experiments usually administer doses to subjects at one time …

Primary prevention measures designed to alter susceptibility and/or reduce exposure of
susceptible individuals to diseases, remain the mainstay in the fight against HIV/AIDS. A …

ABSTRACT A recent experiment involving simian immunodeficiency virus (SIV) infection of
macaques revealed that the infectivity of this virus decreased over the first few months of …

The potential of broadly neutralizing antibodies targeting the HIV-1 envelope trimer to
prevent HIV-1 transmission has opened new avenues for therapies and vaccines. However …