Androgens are an important and diverse group of steroid hormone molecular species. They
play varied functional roles, such as the control of metabolic energy fate and partition, the …

Androgens play an important role in metabolic homeostasis and reproductive health in both
men and women. Androgen signalling is dependent on androgen receptor activation, mostly …

Fibromyalgia (FM) is a prevalent syndrome, characterised by chronic widespread pain,
fatigue, and impaired sleep, that is challenging to diagnose and difficult to treat. The …

Dihydrotestosterone (DHT) is regarded as the most potent natural androgen and is
implicated in the development and progression of castration resistant prostate cancer …

The human adrenal produces more 19 carbon (C 19) steroids, by mass, than either
glucocorticoids or mineralocorticoids. However, the mechanisms regulating adrenal C 19 …

Endogenous Cushing's syndrome (CS) is a rare endocrine condition frequently caused by a
tumor resulting in elevated cortisol levels. Cushing's disease (CD) caused by an …

Commensal bacteria and their genes associated with host are known as microbiome. In
recent years, microbial influence on host endocrine system has been under detailed …

This review briefly addresses the history of the discovery and elucidation of the three cloned
11β-hydroxysteroid dehydrogenase (11βHSD) enzymes in the human, 11βHSD1, 11βHSD2 …

The androgen precursors, dehydroepiandrosterone (DHEA) and DHEA sulfate (DHEAS) are
produced in high amounts by the adrenal cortex primarily in humans and a few other …

Adrenal C 19 steroids serve as precursors to active androgens in the prostate.
Androstenedione (A4), 11β-hydroxyandrostenedione (11OHA4) and 11β …