The case for a renewed focus on Nature in drug discovery is reviewed; not in terms of
natural product screening, but how and why biomimetic molecules, especially those …

Natural products and analogues are a source of antibacterial drug discovery. Considering
drug resistance levels emerging for antibiotics, identification of bacterial metalloenzymes …

Natural products are the result of Nature's exploration of biologically relevant chemical
space through evolution and an invaluable source of bioactive small molecules for chemical …

Interest in therapeutic discovery typically drives the preparation of natural product analogs,
but these undertakings contribute significant advances for synthetic chemistry as well. The …

Natural product-inspired compound collections serve as excellent sources for the
identification of new bioactive compounds to treat disease. However, such compounds must …

Weeds are a permanent component of anthropogenic ecosystems. They require strict control
to avoid the accumulation of their long-lasting seeds in the soil. With high crop infestation …

The number of databases of natural products (NPs) has increased substantially. Latin
America is extraordinarily rich in biodiversity, enabling the identification of novel NPs, which …

Single crystal X-ray diffraction is considered to be a highly reliable method for determining
the molecular structures and absolute conformation at the atomic level, but this technique is …

Natural product (NP)‐inspired design principles provide invaluable guidance for bioactive
compound discovery. Pseudo‐natural products (PNPs) are de novo combinations of NP …

In phenotypic compound discovery, conclusive identification of cellular targets and mode of
action are often impaired by off-target binding. In particular, microtubules are frequently …