The significance of mitochondrial dysfunction in cancer
As an essential organelle in nucleated eukaryotic cells, mitochondria play a central role in
energy metabolism, maintenance of redox balance, and regulation of apoptosis …
energy metabolism, maintenance of redox balance, and regulation of apoptosis …
Fumarate hydratase (FH) and cancer: a paradigm of oncometabolism
L Valcarcel-Jimenez, C Frezza - British Journal of Cancer, 2023 - nature.com
Fumarate hydratase (FH) is an enzyme of the Tricarboxylic Acid (TCA) cycle whose
mutations lead to hereditary and sporadic forms of cancer. Although more than twenty years …
mutations lead to hereditary and sporadic forms of cancer. Although more than twenty years …
Fumarate is an epigenetic modifier that elicits epithelial-to-mesenchymal transition
M Sciacovelli, E Gonçalves, TI Johnson, VR Zecchini… - Nature, 2016 - nature.com
Mutations of the tricarboxylic acid cycle enzyme fumarate hydratase cause hereditary
leiomyomatosis and renal cell cancer. Fumarate hydratase-deficient renal cancers are …
leiomyomatosis and renal cell cancer. Fumarate hydratase-deficient renal cancers are …
Metabolic reprogramming and epithelial‐to‐mesenchymal transition in cancer
M Sciacovelli, C Frezza - The FEBS journal, 2017 - Wiley Online Library
Several lines of evidence indicate that during transformation epithelial cancer cells can
acquire mesenchymal features via a process called epithelial‐to‐mesenchymal transition …
acquire mesenchymal features via a process called epithelial‐to‐mesenchymal transition …
LIN28B induces neuroblastoma and enhances MYCN levels via let-7 suppression
JJ Molenaar, R Domingo-Fernández, ME Ebus… - Nature …, 2012 - nature.com
LIN28B regulates developmental processes by modulating microRNAs (miRNAs) of the let-7
family. A role for LIN28B in cancer has been proposed but has not been established in vivo …
family. A role for LIN28B in cancer has been proposed but has not been established in vivo …
Defects in mitochondrial metabolism and cancer
Cancer is a heterogeneous set of diseases characterized by different molecular and cellular
features. Over the past decades, researchers have attempted to grasp the complexity of …
features. Over the past decades, researchers have attempted to grasp the complexity of …
[HTML][HTML] Oncometabolites: Unconventional triggers of oncogenic signalling cascades
M Sciacovelli, C Frezza - Free Radical Biology and Medicine, 2016 - Elsevier
Cancer is a complex and heterogeneous disease thought to be caused by multiple genetic
lesions. The recent finding that enzymes of the tricarboxylic acid (TCA) cycle are mutated in …
lesions. The recent finding that enzymes of the tricarboxylic acid (TCA) cycle are mutated in …
Fumarate hydratase in cancer: A multifaceted tumour suppressor
Cancer is now considered a multifactorial disorder with different aetiologies and outcomes.
Yet, all cancers share some common molecular features. Among these, the reprogramming …
Yet, all cancers share some common molecular features. Among these, the reprogramming …
Genetic alterations in Krebs cycle and its impact on cancer pathogenesis
Cancer cells exhibit alterations in many cellular processes, including oxygen sensing and
energy metabolism. Glycolysis in non-oxygen condition is the main energy production …
energy metabolism. Glycolysis in non-oxygen condition is the main energy production …
Connections between metabolism and epigenetics: mechanisms and novel anti-cancer strategy
C Chen, Z Wang, Y Qin - Frontiers in pharmacology, 2022 - frontiersin.org
Cancer cells undergo metabolic adaptations to sustain their growth and proliferation under
several stress conditions thereby displaying metabolic plasticity. Epigenetic modification is …
several stress conditions thereby displaying metabolic plasticity. Epigenetic modification is …