As an essential organelle in nucleated eukaryotic cells, mitochondria play a central role in
energy metabolism, maintenance of redox balance, and regulation of apoptosis …

Fumarate hydratase (FH) is an enzyme of the Tricarboxylic Acid (TCA) cycle whose
mutations lead to hereditary and sporadic forms of cancer. Although more than twenty years …

Mutations of the tricarboxylic acid cycle enzyme fumarate hydratase cause hereditary
leiomyomatosis and renal cell cancer. Fumarate hydratase-deficient renal cancers are …

Several lines of evidence indicate that during transformation epithelial cancer cells can
acquire mesenchymal features via a process called epithelial‐to‐mesenchymal transition …

LIN28B regulates developmental processes by modulating microRNAs (miRNAs) of the let-7
family. A role for LIN28B in cancer has been proposed but has not been established in vivo …

Cancer is a heterogeneous set of diseases characterized by different molecular and cellular
features. Over the past decades, researchers have attempted to grasp the complexity of …

Cancer is a complex and heterogeneous disease thought to be caused by multiple genetic
lesions. The recent finding that enzymes of the tricarboxylic acid (TCA) cycle are mutated in …

Cancer is now considered a multifactorial disorder with different aetiologies and outcomes.
Yet, all cancers share some common molecular features. Among these, the reprogramming …

Cancer cells exhibit alterations in many cellular processes, including oxygen sensing and
energy metabolism. Glycolysis in non-oxygen condition is the main energy production …

Cancer cells undergo metabolic adaptations to sustain their growth and proliferation under
several stress conditions thereby displaying metabolic plasticity. Epigenetic modification is …