Transforming growth factor-β signaling: from tissue fibrosis to therapeutic opportunities

LL Ren, XJ Li, TT Duan, ZH Li, JZ Yang… - Chemico-biological …, 2023 - Elsevier
Fibrosis refers to the excessive deposition of extracellular matrix components in the
processes of wound repair or tissue regeneration after tissue damage. Fibrosis occurs in …

[HTML][HTML] TGF-β/Smad signaling pathway in tubulointerstitial fibrosis

XY Yu, Q Sun, YM Zhang, L Zou… - Frontiers in pharmacology, 2022 - frontiersin.org
Chronic kidney disease (CKD) was a major public health problem worldwide. Renal fibrosis,
especially tubulointerstitial fibrosis, is final manifestation of CKD. Many studies have …

Guidelines on the Use of therapeutic apheresis in clinical practice–Evidence‐Based approach from the Writing Committee of the American Society for Apheresis: The …

L Connelly‐Smith, CR Alquist, NA Aqui… - Journal of clinical …, 2023 - Wiley Online Library
Abstract The American Society for Apheresis (ASFA) Journal of Clinical Apheresis (JCA)
Special Issue Writing Committee is charged with reviewing, updating, and categorizing …

[HTML][HTML] Melanin-like nanoparticles: advances in surface modification and tumour photothermal therapy

L Tian, X Li, H Ji, Q Yu, M Yang, L Guo, L Huang… - Journal of …, 2022 - Springer
Currently, tumor treatments are characterized by intelligence, diversity and personalization,
but the therapeutic reagents used are often limited in clinical efficacy due to problems with …

[HTML][HTML] Shenkang injection and its three anthraquinones ameliorates renal fibrosis by simultaneous targeting IƙB/NF-ƙB and Keap1/Nrf2 signaling pathways

LP Luo, P Suo, LL Ren, HJ Liu, Y Zhang… - Frontiers in …, 2021 - frontiersin.org
Oxidative stress and inflammation are important and critical mediators in the development
and progression of chronic kidney disease (CKD) and its complications. Shenkang injection …

Host/microbiota interactions-derived tryptophan metabolites modulate oxidative stress and inflammation via aryl hydrocarbon receptor signaling

YQ Tan, YN Wang, HY Feng, ZY Guo, X Li… - Free Radical Biology …, 2022 - Elsevier
Aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor that induces the
expression of a broad range of downstream genes such as cytochromes P450 enzymes and …

Integrative phosphatidylcholine metabolism through phospholipase A2 in rats with chronic kidney disease

Y Wang, Z Zhang, H Liu, Z Guo, L Zou… - Acta Pharmacologica …, 2023 - nature.com
Dysregulation in lipid metabolism is the leading cause of chronic kidney disease (CKD) and
also the important risk factors for high morbidity and mortality. Although lipid abnormalities …

Intrarenal 1-methoxypyrene, an aryl hydrocarbon receptor agonist, mediates progressive tubulointerstitial fibrosis in mice

G Cao, H Miao, Y Wang, D Chen, X Wu… - Acta Pharmacologica …, 2022 - nature.com
Recent studies have shown that endogenous metabolites act via aryl hydrocarbon receptor
(AhR) signalling pathway in tubulointerstitial fibrosis (TIF) pathogenesis. However, the …

[HTML][HTML] Shenkang injection improves chronic kidney disease by inhibiting multiple renin-angiotensin system genes by blocking the Wnt/β-catenin signalling pathway

YN Wang, HJ Liu, LL Ren, P Suo, L Zou… - Frontiers in …, 2022 - frontiersin.org
Chronic kidney disease (CKD) is a major worldwide public health problem. The increase in
the number of patients with CKD and end-stage kidney disease requesting renal dialysis or …

Aryl hydrocarbon receptor: From pathogenesis to therapeutic targets in aging-related tissue fibrosis

CE Yang, YN Wang, MR Hua, H Miao, YY Zhao… - Ageing research …, 2022 - Elsevier
Aging promotes chronic inflammation, which contributes to fibrosis and decreases organ
function. Fibrosis, the excessive synthesis and deposition of extracellular matrix …