Normal axon development depends on the action of mechanical forces both generated
within the cytoskeleton and outside the cell, but forces of large magnitude or rate cause …

Brain injuries are often characterized by diffusely distributed axonal and vascular damage
invisible to medical imaging techniques. The spatial distribution of mechanical stresses and …

Existing axonal finite element models do not consider sex morphological differences or the
fidelity in dynamic input. To facilitate a systematic investigation into the micromechanics of …

Uniaxial stretch is believed to drive diffuse axonal injury (DAI) in mild traumatic brain injury
(mTBI). Axonal varicosities are enlarged structures along axonal shafts and represent a …

Impact-induced brain strains are spatially rich and intrinsically dynamic. However, the
dynamic information of brain strain is not typically used in any injury investigation. Here, we …

This study aims to provide an overview of the recent developments in understanding
multiscale traumatic brain injury (TBI) mechanisms from a multidisciplinary perspective. TBI …

The gray matter/white matter (GM/WM) boundary of the brain is vulnerable to shear strain
associated with mild traumatic brain injury (mTBI). It is, however, unknown whether GM/WM …

Mounting evidence identifies a higher rate of concussion and longer recovery for female
athletes compared to males playing the same sport [2, 3, 7]. Using a clinically relevant swine …

Background Blood inflammatory biomarkers have emerged as important tools for
diagnosing, assessing treatment responses, and predicting neurodegenerative diseases …

Introduction Alzheimer's disease (AD) presents typically gray matter atrophy and white
matter abnormalities in neuroimaging, suggesting that the gray-white matter boundary could …