Oxidative stress has long been implicated in cardiovascular disease, but more recently, the
role of reactive oxygen species (ROS) in normal physiological signaling has been …

Cell cycle progression is regulated by a wide variety of external factors, amongst them are
growth factors and extracellular matrix factors. During the last decades evidence has been …

A significant amount of reactive oxygen species (ROS) is generated during mitochondrial
oxidative phosphorylation. Several studies have suggested that mtDNA may accumulate …

The inactivation of the p53 gene in a large proportion of human cancers has inspired an
intense search for the encoded protein's physiological and biological properties. Expression …

Gene mutations in invertebrates have been identified that extend life span and enhance
resistance to environmental stresses such as ultraviolet light or reactive oxygen species. In …

Reactive oxygen species (ROS) are thought to be involved in many forms of programmed
cell death. The role of ROS in cell death caused by oxidative glutamate toxicity was studied …

Glutathione (GSH; γ-glutamylcysteinyl glycine) is an abundant and ubiquitous thiol with
proposed roles in the storage and transport of reduced sulphur, the synthesis of proteins and …

Crucial roles in sulphur metabolism and plant defence have been described in recent years
for the tripeptide thiol glutathione. In spite of this, the metabolism of glutathione and its …

Activation of cell division in the root apical meristem after germination is essential for
postembryonic root development. Arabidopsis plants homozygous for a mutation in the …

Abstract Purpose: NF-E2-related factor 2 (Nrf2), a key transcription regulator for antioxidant
and detoxification enzymes, is abundantly expressed in cancer cells. In this study, therefore …