Osteoporosis is a bone disorder with remarkable changes in bone biologic material and
consequent bone structural distraction, affecting millions of people around the world from …

Simple Summary FGFR inhibitors evolved as therapeutic options in cholangiocarcinoma
and urothelial malignancies. Given the implications of FGFR pathway in various …

Soft-tissue calcification is a prominent feature in both chronic kidney disease (CKD) and
experimental Klotho deficiency, but whether Klotho deficiency is responsible for the …

The vitamin D signal transduction system involves a series of cytochrome P450-containing
sterol hydroxylases to generate and degrade the active hormone, 1α, 25-dihydroxyvitamin D …

The family of fibroblast growth factors (FGFs) regulates a plethora of developmental
processes, including brain patterning, branching morphogenesis and limb development …

CYP24A1 is the cytochrome P450 component of the 25-hydroxyvitamin D3-24-hydroxylase
enzyme that catalyzes the conversion of 25-hydroxyvitamin D3 (25-OH-D3) and 1, 25 …

Background—Klotho is known to function as a cofactor for the phosphatonin, fibroblast
growth factor (FGF)-23 at the kidney. FGF-23 levels rise in chronic kidney disease (CKD) …

with the matrix and with the periodicity of negative charges on collagen. Crystals initially
form octacalcium phosphate [Ca8H2 (PO4) 6· 5H2O], which reorganizes and seeds epitaxial …

Most physiological functions originate with the communication between organs. Mouse
genetics has revived this holistic view of physiology through the identification of inter-organ …

Cardiac dysfunction in CKD is characterized by aberrant cardiac remodeling with
hypertrophy and fibrosis. CKD is a state of severe systemic Klotho deficiency, and …