Highlights•RNAi is an important antiviral defense mechanism in insects.•All major classes of
viruses are targets of the antiviral RNAi response.•Viruses encode suppressors that interfere …

Oropouche fever is an emerging zoonotic disease caused by Oropouche virus (OROV), an
arthropod transmitted Orthobunyavirus circulating in South and Central America. During the …

Abstract The PIWI-interacting RNA (piRNA) pathway is essential for transposon silencing in
many model organisms. Its remarkable efficiency relies on a sophisticated amplification …

Vector mosquitoes are responsible for transmission of the majority of arthropod-borne (arbo-
) viruses. Virus replication in these vectors needs to be sufficiently high to permit efficient …

The exogenous siRNA pathway is important in restricting arbovirus infection in mosquitoes.
Less is known about the role of the PIWI-interacting RNA pathway, or piRNA pathway, in …

Highlights•Insect RNA interference (RNAi) pathways detect and restrict viruses.•Dicer-2
detects diverse viral dsRNA signatures and initiates the RNAi pathway.•RNAi may play a …

RNA interference (RNAi) was shown over 18 years ago to be a mechanism by which
arbovirus replication and transmission could be controlled in arthropod vectors. During the …

Zika virus (ZIKV), a flavivirus transmitted primarily by Aedes aegypti, has recently spread
globally in an unprecedented fashion, yet we have a poor understanding of host-microbe …

In Aedes mosquitoes, infections with arthropod-borne viruses (arboviruses) trigger or
modulate the expression of various classes of viral and host-derived small RNAs, including …

Arboviruses are transmitted by distantly related arthropod vectors such as mosquitoes (class
Insecta) and ticks (class Arachnida). RNA interference (RNAi) is the major antiviral …