Speciation of metal drugs, supplements and toxins in media and bodily fluids controls in vitro activities
Studies of metal uptake, metabolism and excretion by single bacterial, yeast, plant and
animal cells is a widespread area of research, yet little is known about the reactivity and …
animal cells is a widespread area of research, yet little is known about the reactivity and …
The mechanism of tumour cell death by metal-based anticancer drugs is not only a matter of DNA interactions
Platinum drugs are extensively used in the clinic to treat cancer, often leading to a palliative
response rather than a cure. While DNA is considered to be the primary target of platinum …
response rather than a cure. While DNA is considered to be the primary target of platinum …
Copper (II) and silver (I) complexes with dimethyl 6-(pyrazine-2-yl) pyridine-3, 4-dicarboxylate (py-2pz): the influence of the metal ion on the antimicrobial potential of …
Dimethyl 6-(pyrazine-2-yl) pyridine-3, 4-dicarboxylate (py-2pz) was used as a ligand for the
synthesis of new copper (II) and silver (I) complexes,[CuCl2 (py-2pz)] 2 (1),[Cu …
synthesis of new copper (II) and silver (I) complexes,[CuCl2 (py-2pz)] 2 (1),[Cu …
Organoruthenium Prodrugs as a New Class of Cholinesterase and Glutathione‐S‐Transferase Inhibitors
A small library of 17 organoruthenium compounds with the general formula [RuII
(fcl)(chel)(L)] n+ (in which fcl= face capping ligand, chel= chelating bidentate ligand, and L …
(fcl)(chel)(L)] n+ (in which fcl= face capping ligand, chel= chelating bidentate ligand, and L …
Design of a novel thiophene inhibitor of 15-lipoxygenase-1 with both anti-inflammatory and neuroprotective properties
N Eleftheriadis, H Poelman, NGJ Leus… - European journal of …, 2016 - Elsevier
Abstract The enzyme 15-lipoxygenase-1 (15-LOX-1) plays a dual role in diseases with an
inflammatory component. On one hand 15-LOX-1 plays a role in pro-inflammatory gene …
inflammatory component. On one hand 15-LOX-1 plays a role in pro-inflammatory gene …
Zinc (II) Complexes with Dimethyl 2, 2′-Bipyridine-4, 5-dicarboxylate: Structure, Antimicrobial Activity and DNA/BSA Binding Study
Two zinc (II) complexes with dimethyl 2, 2′-bipyridine-4, 5-dicarboxylate (py-2py) of the
general formula [Zn (py-2py) X2], X= Cl−(1) and Br−(2) were synthesized and characterized …
general formula [Zn (py-2py) X2], X= Cl−(1) and Br−(2) were synthesized and characterized …
Silver (I) complexes with different pyridine-4, 5-dicarboxylate ligands as efficient agents for the control of cow mastitis associated pathogens
Infections of the cow udder leading to mastitis and lower milk quality are one of the biggest
problems in the dairy industry worldwide. Unfortunately, therapeutic options for the treatment …
problems in the dairy industry worldwide. Unfortunately, therapeutic options for the treatment …
Tailoring copper (II) complexes with pyridine-4, 5-dicarboxylate esters for anti-Candida activity
Five novel copper (II) complexes with pyridine-4, 5-dicarboxylate esters as ligands,[Cu
(NO3)(py-2tz)(H2O) 3] NO3 (1),[Cu (NO3) 2 (py-2metz)(H2O)](2),[Cu (NO3) 2 (py …
(NO3)(py-2tz)(H2O) 3] NO3 (1),[Cu (NO3) 2 (py-2metz)(H2O)](2),[Cu (NO3) 2 (py …
Organoruthenium (II) complexes of acetazolamide potently inhibit human carbonic anhydrase isoforms I, II, IX and XII
Two acetazolamide (AAZ) complexes with ruthenium (II) η6-p-cymene chloride were
synthesised, characterised and tested for their inhibitory effects on several carbonic …
synthesised, characterised and tested for their inhibitory effects on several carbonic …
Activity‐Based Probes for 15‐Lipoxygenase‐1
N Eleftheriadis, SA Thee… - Angewandte Chemie …, 2016 - Wiley Online Library
Abstract Human 15‐lipoxygenase‐1 (15‐LOX‐1) plays an important role in several
inflammatory lung diseases, such as asthma, COPD, and chronic bronchitis, as well as …
inflammatory lung diseases, such as asthma, COPD, and chronic bronchitis, as well as …