Obesity and associated chronic inflammation were shown to facilitate breast cancer (BC)
growth and metastasis. Leptin, adiponectin, estrogen, and several pro-inflammatory …

The identification of the estrogen receptor (ER) in the laboratory provided a mechanism to
describe the target site specificity of estrogen action in uterus, vagina, pituitary gland, and …

We have cloned and sequenced the complete complementary DNA of the oestrogen
receptor (ER) present in the breast cancer cell line MCF-7. The expression of the ER cDNA …

The mechanism by which the estrogen receptor and other steroid hormone receptors
regulate gene expression in eukaryotic cells is not well understood. In this study, a …

The existence of a putative membrane estrogen receptor (ER) has been supported by
studies accomplished over the past 20 yr. However, the origin and functions of this receptor …

Poly (A)+ RNA isolated from the human breast cancer cell line MCF-7 was fractionated by
sucrose gradient centrifugation and fractions enriched in estrogen receptor (ER) mRNA …

Extracts containing wild-type or mutant human estrogen receptor (ER) have been used to
study the binding of ER to its responsive element (ERE). Estradiol (E2) or the antiestrogen …

Functional evidence for the existence of plasma membrane estrogen receptors in a variety of
cell types continues to accumulate. Many of these functions originate from rapid signaling …

Estrogen and progesterone receptors (ER and PR) have now been studied in clinical breast
cancer for more than 20 years. Positive receptor status correlates with favorable prognostic …

The mouse estrogen receptor was shown to be constantly shuttling between the nucleus
and cytoplasm although under steady-state conditions it is detected predomi-nantly in the …