The biology of the HIV-1 latent reservoir and implications for cure strategies
Antiretroviral therapy (ART) inhibits HIV replication but is not curative. During ART, the
integrated HIV genome persists indefinitely within CD4+ T cells and perhaps other cells …
integrated HIV genome persists indefinitely within CD4+ T cells and perhaps other cells …
Targeting the latent reservoir for HIV-1
S Sengupta, RF Siliciano - Immunity, 2018 - cell.com
Antiretroviral therapy can effectively block HIV-1 replication and prevent or reverse
immunodeficiency in HIV-1-infected individuals. However, viral replication resumes within …
immunodeficiency in HIV-1-infected individuals. However, viral replication resumes within …
HIV infection: epidemiology, pathogenesis, treatment, and prevention
G Maartens, C Celum, SR Lewin - The Lancet, 2014 - thelancet.com
HIV prevalence is increasing worldwide because people on antiretroviral therapy are living
longer, although new infections decreased from 3· 3 million in 2002, to 2· 3 million in 2012 …
longer, although new infections decreased from 3· 3 million in 2002, to 2· 3 million in 2012 …
[HTML][HTML] Recommendations for measuring HIV reservoir size in cure-directed clinical trials
M Abdel-Mohsen, D Richman, RF Siliciano… - Nature medicine, 2020 - nature.com
Therapeutic strategies are being clinically tested either to eradicate latent HIV reservoirs or
to achieve virologic control in the absence of antiretroviral therapy. Attaining this goal will …
to achieve virologic control in the absence of antiretroviral therapy. Attaining this goal will …
In vivo suppression of HIV rebound by didehydro-cortistatin A, a “block-and-lock” strategy for HIV-1 treatment
HIV-1 Tat activates viral transcription and limited Tat transactivation correlates with latency
establishment. We postulated a" block-and-lock" functional cure approach based on …
establishment. We postulated a" block-and-lock" functional cure approach based on …
Application of CRISPR/Cas9-based gene editing in HIV-1/AIDS therapy
Q Xiao, D Guo, S Chen - Frontiers in cellular and infection …, 2019 - frontiersin.org
Despite the fact that great efforts have been made in the prevention and therapy of HIV-1
infection, HIV-1/AIDS remains a major threat to global human health. Highly active …
infection, HIV-1/AIDS remains a major threat to global human health. Highly active …
Comparative analysis of measures of viral reservoirs in HIV-1 eradication studies
HIV-1 reservoirs preclude virus eradication in patients receiving highly active antiretroviral
therapy (HAART). The best characterized reservoir is a small, difficult-to-quantify pool of …
therapy (HAART). The best characterized reservoir is a small, difficult-to-quantify pool of …
Tissue reservoirs of HIV
JK Wong, SA Yukl - Current Opinion in HIV and AIDS, 2016 - journals.lww.com
The retention of infected cells in a wide variety of tissues, often with distinct viral and cellular
characteristics, underscores the importance of studying tissue reservoirs in the development …
characteristics, underscores the importance of studying tissue reservoirs in the development …
Evidence for the cure of HIV infection by CCR5Δ32/Δ32 stem cell transplantation
K Allers, G Hütter, J Hofmann… - Blood, The Journal …, 2011 - ashpublications.org
HIV entry into CD4+ cells requires interaction with a cellular receptor, generally either CCR5
or CXCR4. We have previously reported the case of an HIV-infected patient in whom viral …
or CXCR4. We have previously reported the case of an HIV-infected patient in whom viral …
The role of macrophages in HIV-1 persistence and pathogenesis
Z Kruize, NA Kootstra - Frontiers in microbiology, 2019 - frontiersin.org
Current antiretroviral therapy (ART) effectively suppresses Human Immunodeficiency Virus
type 1 (HIV-1) in infected individuals. However, even long term ART does not eradicate HIV …
type 1 (HIV-1) in infected individuals. However, even long term ART does not eradicate HIV …