Regulation of pancreatic beta-cell mass
L Bouwens, I Rooman - Physiological reviews, 2005 - journals.physiology.org
Beta-cell mass regulation represents a critical issue for understanding diabetes, a disease
characterized by a near-absolute (type 1) or relative (type 2) deficiency in the number of …
characterized by a near-absolute (type 1) or relative (type 2) deficiency in the number of …
Biological and biomaterial approaches for improved islet transplantation
AS Narang, RI Mahato - Pharmacological reviews, 2006 - ASPET
Islet transplantation may be used to treat type I diabetes. Despite tremendous progress in
islet isolation, culture, and preservation, the clinical use of this modality of treatment is …
islet isolation, culture, and preservation, the clinical use of this modality of treatment is …
[HTML][HTML] In vitro generation of insulin-producing beta cells from adult exocrine pancreatic cells
L Baeyens, S De Breuck, J Lardon, JK Mfopou… - Diabetologia, 2005 - Springer
Aims/hypothesis Transplantation of insulin-producing beta cells from donors can cure
diabetes, but they are available in insufficient quantities. In this study, we investigated the …
diabetes, but they are available in insufficient quantities. In this study, we investigated the …
Human β-cell proliferation and intracellular signaling part 2: still driving in the dark without a road map
E Bernal-Mizrachi, RN Kulkarni, DK Scott… - Diabetes, 2014 - Am Diabetes Assoc
Enhancing β-cell proliferation is a major goal for type 1 and type 2 diabetes research.
Unraveling the network of β-cell intracellular signaling pathways that promote β-cell …
Unraveling the network of β-cell intracellular signaling pathways that promote β-cell …
Pancreatic β-cell growth and survival–a role in obesity-linked type 2 diabetes?
MK Lingohr, R Buettner, CJ Rhodes - Trends in molecular medicine, 2002 - cell.com
Obesity-linked type 2 diabetes is a disease of insulin resistance combined with pancreatic β-
cell dysfunction. Although a role for β-cell mass in the pathogenesis of obesity-linked type 2 …
cell dysfunction. Although a role for β-cell mass in the pathogenesis of obesity-linked type 2 …
Activin A and betacellulin: effect on regeneration of pancreatic β-cells in neonatal streptozotocin-treated rats
Activin A and betacellulin (BTC) are thought to regulate differentiation of pancreatic β-cells
during development and regeneration of β-cells in adults. In the present study, we used …
during development and regeneration of β-cells in adults. In the present study, we used …
Expansion and redifferentiation of adult human pancreatic islet cells
L Ouziel-Yahalom, M Zalzman, L Anker-Kitai… - Biochemical and …, 2006 - Elsevier
β-cell replacement represents the ultimate cure for type 1 diabetes, however it is limited by
availability of organ donors. Adult human islets are difficult to propagate in culture, and …
availability of organ donors. Adult human islets are difficult to propagate in culture, and …
[HTML][HTML] Derivation of insulin-producing cells from human embryonic stem cells
D Van Hoof, KA D'Amour, MS German - Stem cell research, 2009 - Elsevier
The potential of pluripotent human cells, such as human embryonic stem cells (hESCs) and
induced pluripotent stem (iPS) cells, to differentiate into any adult cell type makes them …
induced pluripotent stem (iPS) cells, to differentiate into any adult cell type makes them …
[HTML][HTML] Monosodium glutamate dietary consumption decreases pancreatic β-cell mass in adult Wistar rats
P Boonnate, S Waraasawapati, W Hipkaeo, S Pethlert… - PLoS …, 2015 - journals.plos.org
Background The amount of dietary monosodium glutamate (MSG) is increasing worldwide,
in parallel with the epidemics of metabolic syndrome. Parenteral administration of MSG to …
in parallel with the epidemics of metabolic syndrome. Parenteral administration of MSG to …
[HTML][HTML] ADAM10 mediates ectodomain shedding of the betacellulin precursor activated by p-aminophenylmercuric acetate and extracellular calcium influx
MP Sanderson, SN Erickson, PJ Gough… - Journal of Biological …, 2005 - ASBMB
Betacellulin belongs to the family of epidermal growth factor-like growth factors that are
expressed as transmembrane precursors and undergo proteolytic ectodomain shedding to …
expressed as transmembrane precursors and undergo proteolytic ectodomain shedding to …