Prediction of tumor-reactive T cell receptors from scRNA-seq data for personalized T cell therapy
The identification of patient-derived, tumor-reactive T cell receptors (TCRs) as a basis for
personalized transgenic T cell therapies remains a time-and cost-intensive endeavor …
personalized transgenic T cell therapies remains a time-and cost-intensive endeavor …
Machine learning for the identification of neoantigen-reactive CD8+ T cells in gastrointestinal cancer using single-cell sequencing
H Sun, X Han, Z Du, G Chen, T Guo, F Xie… - British Journal of …, 2024 - nature.com
Background It appears that tumour-infiltrating neoantigen-reactive CD8+ T (Neo T) cells are
the primary driver of immune responses to gastrointestinal cancer in patients. However, the …
the primary driver of immune responses to gastrointestinal cancer in patients. However, the …
Heterogeneous expression of ARID1A in colorectal cancer indicates distinguish immune landscape and efficacy of immunotherapy
X Guan, L Cui, Y Ruan, L Fang, T Dang, Y Zhang… - Discover Oncology, 2024 - Springer
Objective AT-rich interaction domain 1A (ARID1A) mutant tumors show active anti-tumor
immune response, which is the potential indication of immunotherapy. However, the …
immune response, which is the potential indication of immunotherapy. However, the …
[HTML][HTML] T-Cell-Based Platform for Functional Screening of T-Cell Receptors Identified in Single-Cell RNA Sequencing Data Sets of Tumor-Infiltrating T-Cells
AR Ehrenfried, S Zens, LK Steffens, H Kehm, A Paul… - Bio …, 2024 - ncbi.nlm.nih.gov
The advent of single-cell RNA sequencing (scRNAseq) has enabled in-depth gene
expression analysis of several thousand cells isolated from tissues. We recently reported the …
expression analysis of several thousand cells isolated from tissues. We recently reported the …