CLC anion transporters are found in all phyla and form a gene family of eight members in
mammals. Two CLC proteins, each of which completely contains an ion translocation …

The protonation state of soluble and membrane-associated macromolecules dictates their
charge, conformation, and functional activity. In addition, protons (H+ or their equivalents) …

The ability to control cell volume is pivotal for cell function. Cell volume perturbation elicits a
wide array of signaling events, leading to protective (eg, cytoskeletal rearrangement) and …

Membrane traffic in eukaryotic cells involves transport of vesicles that bud from a donor
compartment and fuse with an acceptor compartment. Common principles of budding and …

Tissue-resident phagocytes are responsible for the routine binding, engulfment, and
resolution of their meals. Such populations of cells express appropriate surface receptors …

Developing networks follow common rules to shift from silent cells to coactive networks that
operate via thousands of synapses. This review deals with some of these rules and in …

X-linked intellectual disability (XLID) is a clinically and genetically heterogeneous disorder.
During the past two decades in excess of 100 X-chromosome ID genes have been …

Cl− channels reside both in the plasma membrane and in intracellular organelles. Their
functions range from ion homeostasis to cell volume regulation, transepithelial transport, and …

For more than 25 years, it has been widely appreciated that Ca2+ influx is essential to
trigger T‐lymphocyte activation. Patch clamp analysis, molecular identification, and …

Chloride channels play important roles in the plasma membrane and in intracellular
organelles. Mice deficient for the ubiquitously expressed ClC-7 Cl− channel show severe …