Super-resolution imaging techniques that overcome the diffraction limit of light have gained
wide popularity for visualizing cellular structures with nanometric resolution. Following the …

Super-resolution microscopy (SRM) bypasses the diffraction limit, a physical barrier that
restricts the optical resolution to roughly 250 nm and was previously thought to be …

In eukaryotes, higher-order chromatin organization is spatiotemporally regulated as
domains, for various cellular functions. However, their physical nature in living cells remains …

Super-resolved structured illumination microscopy (SR-SIM) is among the most rapidly
growing fluorescence microscopy techniques that can surpass the optical diffraction limit …

Enabling the cellular delivery and cytosolic bioavailability of functional proteins constitutes a
major challenge for the life sciences. Here we demonstrate that thiol-reactive arginine-rich …

Functional antibody delivery in living cells would enable the labelling and manipulation of
intracellular antigens, which constitutes a long-thought goal in cell biology and medicine …

The interplay between replication stress and the S phase checkpoint is a key determinant of
genome maintenance, and has a major impact on human diseases, notably, tumour …

Chromatin in eukaryotic cells is a negatively charged polymer composed of DNA, histones,
and various associated proteins. Over the past ten years, our view of chromatin has shifted …

The review begins with a concise description of the principles of phase separation. This is
followed by a comprehensive section on phase separation of chromatin, in which we recount …

DNA damage-induced signaling by ATR and CHK1 inhibits DNA replication, stabilizes
stalled and collapsed replication forks, and mediates the repair of multiple classes of DNA …