Call for next-generation drugs that remove the uptake barrier to combat antibiotic resistance

B Peng, H Li, X Peng - Drug Discovery Today, 2023 - Elsevier
Existing antibacterial agents can be categorized into two generations, but bacterial
insensitivity towards both of these classes poses a serious public health challenge …

Bacterial persister cells and development of antibiotic resistance in chronic infections: an update

AP Kunnath, M Suodha Suoodh… - British Journal of …, 2024 - frontierspartnerships.org
The global issue of antimicrobial resistance poses significant challenges to public health.
The World Health Organization (WHO) has highlighted it as a major global health threat …

[HTML][HTML] Fructose-enabled killing of antibiotic-resistant Salmonella enteritidis by gentamicin: Insight from reprogramming metabolomics

M Jiang, X Li, CL Xie, P Chen, W Luo, C Lin… - International Journal of …, 2023 - Elsevier
Salmonella enterica is a food-borne pathogen that poses a severe threat to both poultry
production and human health. Antibiotics are critical for the initial treatment of bacterial …

Exogenous pyruvate promotes gentamicin uptake to kill antibiotic-resistant Vibrio alginolyticus

S Kuang, J Xiang, Y Chen, X Peng, H Li… - International journal of …, 2024 - Elsevier
Objectives Elucidating antibiotic resistance mechanisms is necessary for developing novel
therapeutic strategies. The increasing incidence of antibiotic-resistant Vibrio alginolyticus …

Exogenous L‐Alanine promotes phagocytosis of multidrug‐resistant bacterial pathogens

M Jiang, XH Chen, H Li, XX Peng, B Peng - EMBO reports, 2023 - embopress.org
Multidrug‐resistant bacteria present a major threat to public health that urgently requires
new drugs or treatment approaches. Here, we conduct integrated proteomic and …

Photothermal responsive porous hollow microneedles as Chinese medicine versatile delivery system for wound healing

W Zhang, L Cai, J Gan, Y Zhao - Smart Medicine, 2024 - Wiley Online Library
Chinese medicine is identified as a candidate for wound healing. Attempts in this field tend
to develop efficient dosage forms for delivering Chinese medicine with low side effects. In …

In-patient evolution of a high-persister Escherichia coli strain with reduced in vivo antibiotic susceptibility

JB Parsons, AE Sidders, AZ Velez… - Proceedings of the …, 2024 - National Acad Sciences
Gram-negative bacterial bloodstream infections (GNB-BSI) are common and frequently
lethal. Despite appropriate antibiotic treatment, relapse of GNB-BSI with the same bacterial …

Metabolomics Method in Understanding and Sensitizing Carbapenem-Resistant Acinetobacter baumannii to Meropenem

X Li, D Feng, J Zhou, W Wu, W Zheng… - ACS Infectious …, 2023 - ACS Publications
Carbapenem-resistant Acinetobacter baumannii (CRAB) strains are prevalent worldwide
and represent a major threat to public health. However, treatment options for infections …

Functional Proteomics Analysis of Norfloxacin-Resistant Edwardsiella tarda

J Wu, D Li, X Tan, X Chen, Y Liu… - Journal of Proteome …, 2023 - ACS Publications
Multidrug-resistant Edwardsiella tarda threatens both sustainable aquaculture and human
health, but the control measure is still lacking. In this study, we adopted functional …

Innovative fluorescence sensing platform for β-lactams based on acidity/basicity-sensitive graphdiyne quantum dots

G Zhu, D Liao, J Li, Y Yi - Chemical Communications, 2024 - pubs.rsc.org
Residues of β-lactam antibiotics (β-LA) in the environment have posed a great threat to
human health, while lacking a simple, effective, and universal sensing method. Herein, basic …