Polycomb function in early mouse development
Epigenetic factors are crucial for ensuring proper chromatin dynamics during the initial
stages of embryo development. Among these factors, the Polycomb group (PcG) of proteins …
stages of embryo development. Among these factors, the Polycomb group (PcG) of proteins …
Navigating the complexity of Polycomb repression: Enzymatic cores and regulatory modules
S Tamburri, S Rustichelli, S Amato, D Pasini - Molecular Cell, 2024 - cell.com
Polycomb proteins are a fundamental repressive system that plays crucial developmental
roles by orchestrating cell-type-specific transcription programs that govern cell identity …
roles by orchestrating cell-type-specific transcription programs that govern cell identity …
[HTML][HTML] Genome-scale exon perturbation screens uncover exons critical for cell fitness
CRISPR-Cas technology has transformed functional genomics, yet understanding of how
individual exons differentially shape cellular phenotypes remains limited. Here, we …
individual exons differentially shape cellular phenotypes remains limited. Here, we …
PICKLE-mediated nucleosome condensing drives H3K27me3 spreading for the inheritance of Polycomb memory during differentiation
Z Liang, T Zhu, Y Yu, C Wu, Y Huang, Y Hao, X Song… - Molecular Cell, 2024 - cell.com
Spreading of H3K27me3 is crucial for the maintenance of mitotically inheritable Polycomb-
mediated chromatin silencing in animals and plants. However, how Polycomb repressive …
mediated chromatin silencing in animals and plants. However, how Polycomb repressive …
[HTML][HTML] The Functional Relationship between RNA Splicing and the Chromatin Landscape
JC Yustis, M Devoucoux, J Côté - Journal of Molecular Biology, 2024 - Elsevier
Chromatin is a highly regulated and dynamic structure that has been shown to play an
essential role in transcriptional and co-transcriptional regulation. In the context of RNA …
essential role in transcriptional and co-transcriptional regulation. In the context of RNA …
[HTML][HTML] H3K27me3-mediated epigenetic regulation in pluripotency maintenance and lineage differentiation
Cell fate determination is an intricate process which is orchestrated by multiple regulatory
layers including signal pathways, transcriptional factors, epigenetic modifications, and …
layers including signal pathways, transcriptional factors, epigenetic modifications, and …