The importance of the pyrazole scaffold in the design of protein kinases inhibitors as targeted anticancer therapies
The altered activation or overexpression of protein kinases (PKs) is a major subject of
research in oncology and their inhibition using small molecules, protein kinases inhibitors …
research in oncology and their inhibition using small molecules, protein kinases inhibitors …
Novel 1, 3, 5-triazine-based pyrazole derivatives as potential antitumor agents and EFGR kinase inhibitors: Synthesis, cytotoxicity, DNA binding, molecular docking …
We herein report the design and synthesis of new 1, 3, 5-triazine-based pyrazole derivatives
(5a–i) with anticancer activity targeting the epidermal growth factor (EGFR) tyrosine kinase …
(5a–i) with anticancer activity targeting the epidermal growth factor (EGFR) tyrosine kinase …
An insight into the synthesis and SAR of 2, 4-thiazolidinediones (2, 4-TZD) as multifunctional scaffold: a review
NS Sethi, DN Prasad, RK Singh - Mini Reviews in Medicinal …, 2020 - ingentaconnect.com
2, 4-Thiazolidinedione (2, 4-TZD) is a versatile pharmacophore, a privileged scaffold, and a
remarkable sulphur-containing heterocyclic compound with diverse pharmacological …
remarkable sulphur-containing heterocyclic compound with diverse pharmacological …
Synthesis and molecular docking study of new pyrazole derivatives as potent anti-breast cancer agents targeting VEGFR-2 kinase
DH Dawood, ES Nossier, MM Ali, AE Mahmoud - Bioorganic Chemistry, 2020 - Elsevier
Based on the previous studies that revealed the valuable role of pyrazole scaffold in cancer
management and VEGFR-2 inhibition, a new set of pyrazole conjugated with pyrazoline …
management and VEGFR-2 inhibition, a new set of pyrazole conjugated with pyrazoline …
[PDF][PDF] armacia Farmacia F
A ANDRIEŞ - 2014 - researchgate.net
Squalene is a natural dehydrotriterpenic hydrocarbon (C30H50) with six double bonds, an
intermediate for the biosynthesis of phytosterol/cholesterol in plants/animals and humans …
intermediate for the biosynthesis of phytosterol/cholesterol in plants/animals and humans …
New pyrrole derivatives as promising biological agents: design, synthesis, characterization, in silico, and cytotoxicity evaluation
BC Ivan, SF Barbuceanu, CM Hotnog… - International Journal of …, 2022 - mdpi.com
The current study describes the synthesis, physicochemical characterization and cytotoxicity
evaluation of a new series of pyrrole derivatives in order to identify new bioactive molecules …
evaluation of a new series of pyrrole derivatives in order to identify new bioactive molecules …
Toxicity of plant extracts containing pyrrolizidine alkaloids using alternative invertebrate models
Pyrrolizidine alkaloids (PAs) are a widespread class of hepatotoxic heterocyclic organic
compounds found in approximately 3% of world flora. Some PAs have been shown to have …
compounds found in approximately 3% of world flora. Some PAs have been shown to have …
AC-SO3H/[CholineCl][Urea] 2 as a green catalytic system for the synthesis of pyrano [2, 3-c] pyrazole scaffolds
HT Nguyen, T Van Le, PH Tran - Journal of Environmental Chemical …, 2021 - Elsevier
A sulfonated amorphous carbon (AC-SO 3 H) was prepared from rice husk with sulfuric acid
and fully characterized using FT-IR spectroscopy, X-ray diffraction (XRD), scanning electron …
and fully characterized using FT-IR spectroscopy, X-ray diffraction (XRD), scanning electron …
Synthesis, characterization, antimicrobial and antiproliferative activity evaluation of Cu (II), Co (II), Zn (II), Ni (II) and Pt (II) complexes with isoniazid-derived compound
E Pahonțu, DC Ilieș, S Shova, C Oprean, V Păunescu… - Molecules, 2017 - mdpi.com
Hydrazone complexes of Cu (II), Co (II), Zn (II), Ni (II) and Pt (II) with N-isonicotinoyl-N′-(3-
metoxy-2 hydroxybenzaldehyde)-hydrazone (HL) were synthesized and characterized by …
metoxy-2 hydroxybenzaldehyde)-hydrazone (HL) were synthesized and characterized by …
Design, synthesis, and docking studies of novel pyrazole-based scaffolds and their evaluation as VEGFR2 inhibitors in the treatment of prostate cancer
DH Soliman, MS Nafie - RSC advances, 2023 - pubs.rsc.org
Since VEGFR-2 plays a crucial role in tumor growth, angiogenesis, and metastasis, it is a
prospective target for cancer treatment. In this work, a series of 3-phenyl-4-(2-substituted …
prospective target for cancer treatment. In this work, a series of 3-phenyl-4-(2-substituted …