There are several interrelated mechanisms involving iron, dopamine, and neuromelanin in
neurons. Neuromelanin accumulates during aging and is the catecholamine-derived …

The molecular mechanisms causing the loss of dopaminergic neurons containing
neuromelanin in the substantia nigra and responsible for motor symptoms of Parkinson's …

The diagnosis of Parkinson's disease (PD) occurs after pathogenesis is advanced and many
substantia nigra (SN) dopamine neurons have already died. Now that therapies to block this …

Despite considerable advances in the past decade, melanin research still suffers from the
lack of universally accepted and shared nomenclature, methodologies, and structural …

Dopaminergic neurons of the substantia nigra selectively degenerate over the course of
Parkinson's disease. These neurons are also the most heavily pigmented cells of the brain …

The dark pigment neuromelanin (NM) is abundant in cell bodies of dopamine (DA) neurons
in the substantia nigra (SN) and norepinephrine (NE) neurons in the locus coeruleus (LC) in …

Neuromelanin (NM) is a dark polymer pigment produced in specific populations of
catecholaminergic neurons in the brain. It appears in greatest quantities in the human brain …

During aging, neuronal organelles filled with neuromelanin (a dark-brown pigment) and lipid
bodies accumulate in the brain, particularly in the substantia nigra, a region targeted in …

Substantial evidence implies that redox imbalance attributable to an overproduction of
reactive oxygen species or reactive nitrogen species that overwhelm the protective defense …

Background We present a lipidomics analysis of human Parkinson's disease tissues. We
have focused on the primary visual cortex, a region that is devoid of pathological changes …