Vascular epidermal growth factor receptor-2 (VEGFR-2), as an important tyrosine
transmembrane protein, plays an important role in regulating endothelial cell proliferation …

Hypoxia and free radicals, such as reactive oxygen and nitrogen species, can alter the
function and/or activity of the transcription factor hypoxia-inducible factor 1 (HIF1). Interplay …

Bone marrow-derived cells contribute to tumor angiogenesis. Here, we demonstrate that
monocytes expressing the Tie2 receptor (Tie2-expressing monocytes [TEMs])(1) are a …

The corpus luteum (CL) is one of the few endocrine glands that forms from the remains of
another organ and whose function and survival are limited in scope and time. The CL is the …

Dicer is a key enzyme involved in the maturation of microRNAS (miRNAs). miRNAs have
been shown to be regulators of gene expression participating in the control of a wide range …

Abstracts The Angiopoietin/Tie system acts as a vascular specific ligand/receptor system to
control endothelial cell survival and vascular maturation. The Angiopoietin family includes …

The receptor tyrosine kinase Tie2, and its activating ligand Angiopoietin-1 (Ang1), are
required for vascular remodelling and vessel integrity, whereas Ang2 may counteract these …

Retinal and choroidal neovascularization (NV) and vascular leakage contribute to visual
impairment in several common ocular diseases. The angiopoietin/TIE2 (ANG/TIE2) pathway …

Tie2 belongs to the receptor tyrosine kinase family and functions as a receptor for
Angiopoietin-1 (Ang1). Gene-targeting analyses of either Ang1 or Tie2 in mice reveal a …

Dysregulation of Axl and its ligand growth arrest-specific 6 is implicated in the pathogenesis
of several human cancers. In this study, we have used RNAi and monoclonal antibodies to …