The immediate-early gene product and zinc finger transcription factor early growth response
(Egr)-1 plays a key master regulatory role in multiple cardiovascular pathological processes …

Intestinal ischemia‐reperfusion (II/R) injury is a common type of tissue and organ injury,
secondary to intestinal and mesenteric vascular diseases. II/R is characterized by a high …

High expression of epidermal growth factor receptor (EGFR) is found in a variety of solid
tumors, including colorectal cancer. EGFR has been identified as a rational target for …

Aim To examine whether protein kinase C (PKC) and associated downstream mechanisms
are involved in hyperglycaemia (HG)‐evoked blood–brain barrier (BBB) damage. Methods …

Myocardial ischemia is one of the main causes of sudden cardiac death worldwide.
Depending on the cell type and stimulus, ERK activity mediates different anti-proliferative …

Myocardial infarction, stroke, and venous thromboembolism are characterized by oxygen
deprivation. In hypoxia, biological responses are activated that evoke tissue damage. Rapid …

Hypoxia, as occurs during tissue ischemia, tips the natural anticoagulant/procoagulant
balance of the endovascular wall to favor activation of coagulation. Plasminogen activator …

Objective—Subjects with diabetes mellitus are at high risk for developing atherosclerosis
through a variety of mechanisms. Because the metabolism of glucose results in production …

Endothelial activation is a central initiating event in atheroma formation. Evidence from our
laboratory and others has demonstrated links between activation of early growth response-1 …

1 The nuclear translocation of transcription factors may be a critical factor in the intracellular
pathway involved in ischaemia/reperfusion (I/R) injury. Here, we examined whether NF‐κB …