The fibroblast growth factor (FGF) family is composed of 18 secreted signaling proteins
consisting of canonical FGFs and endocrine FGFs that activate four receptor tyrosine …

Since its discovery 40 years ago, fibroblast growth factor (FGF) receptor (FGFR) signalling
has been found to regulate fundamental cellular behaviours in a wide range of cell types …

Somatic hotspot mutations and structural amplifications and fusions that affect fibroblast
growth factor receptor 2 (encoded by FGFR2) occur in multiple types of cancer. However …

Mammalian target of rapamycin (mTOR), a regulator of growth in many tissues, mediates its
activity through two multiprotein complexes, mTORC1 or mTORC2. The role of mTOR …

The epidermis, the outmost layer of the skin, is a stratified squamous epithelium that protects
the body from the external world. The epidermis and its appendages need constantly renew …

Fibroblast growth factor (FGF)/Fibroblast growth factor receptor (FGFR) signaling regulates
various cellular processes during the embryonic development and in the adult organism. In …

It is well established that the interaction between cancer cells and microenvironment has a
critical role in tumor development, but the roles of miRNAs in this interaction are rarely …

Cutaneous squamous cell carcinoma (cSCC) represents 20% of all skin cancers. Although
primary cSCC s can be successfully treated with surgery, a subset of highly aggressive …

Basosquamous carcinoma (BSC) is an aggressive skin neoplasm with the features of both
basal cell carcinoma (BCC) and squamous cell carcinoma (SCC). While genetic drivers of …

Simple Summary Cutaneous squamous cell carcinoma (cSCC) is a complex disease arising
from an interplay of UV-induced DNA damage, genetic mutations, and alterations in the …