Premature ovarian insufficiency (POI) is the loss of normal ovarian function before the age of
40 years, a condition that affects approximately 1% of women under 40 years old and 0.1 …

About 10% of women of reproductive age are unable to conceive or carry a pregnancy to
term. Female factors alone account for at least 35% of all infertility cases and comprise a …

Understanding the physiology underlying the complex dialog between the oocyte and its
surrounding somatic cells within the ovarian follicle has been crucial in defining optimal …

Primary ovarian insufficiency (POI) is determined by exhaustion of follicles in the ovaries,
which leads to infertility before the age of 40 years. It is characterized by a strong familial …

In order to reveal the complex mechanism governing the mitotic/meiotic switch in female
germ cells at epigenomic and genomic levels, we examined the chromatin accessibility …

Ovarian deficiency, including premature ovarian insufficiency (POI) and diminished ovarian
reserve (DOR), represents one of the main causes of female infertility. POI is a genetically …

Two of the most prevalent ovarian diseases affecting women's fertility and health are Primary
Ovarian Insufficiency (POI) and Polycystic Ovarian Syndrome (PCOS). Previous studies …

Primary ovarian insufficiency (POI) is characterized by amenorrhea, increased follicle-
stimulating hormone (FSH) levels, and hypoestrogenism, leading to infertility before the age …

Background Bone morphogenetic protein 15 (BMP15) is expressed in oocytes and plays a
crucial role in the reproduction of mono-ovulating species. In humans, BMP15 gene …

We established an efficient and simplified single-cell proteomics (ES–SCP) workflow to
realize proteomics profiling at the single-oocyte level. With the ES–SCP workflow, we …