Background Epigenetics is the study of processes—beyond DNA sequence alteration—
producing heritable characteristics. For example, DNA methylation modifies gene …

Formation of skeletal muscle fibers (myogenesis) during development and after tissue injury
in the adult constitutes an excellent paradigm to investigate the mechanisms whereby …

Emerging studies document the roles of long non-coding RNAs (LncRNAs) in regulating
gene expression at chromatin level but relatively less is known how they regulate DNA …

Differentiation-related DNA methylation is receiving increasing attention, partly owing to
new, whole-genome analyses. These revealed that cell type-specific differential methylation …

The development of ectothermic embryos is strongly affected by incubation temperature, and
thermal imprinting of body growth and muscle phenotype has been reported in various …

We looked at a disease-associated macrosatellite array D4Z4 and focused on epigenetic
factors influencing its chromatin state outside of the disease-context. We used the HCT116 …

Myogenin (myog) encodes a highly conserved myogenic regulatory factor that is involved in
terminal muscle differentiation. It has been shown in mammals that methylation of cytosines …

Remodelling the methylome is a hallmark of mammalian development and cell
differentiation. However, current knowledge of DNA methylation dynamics in human tissue …

Myogenic cell cultures derived from muscle biopsies are excellent models for human cell
differentiation. We report the first comprehensive analysis of myogenesis-specific DNA hyper …

Sufficient quantity and quality of skeletal muscle is required to maintain lifespan and
healthspan into older age. The concept of skeletal muscle programming/memory has been …