The extracellular signal-regulated kinase 1/2 (ERK1/2) cascade is a central signaling
pathway that regulates a wide variety of stimulated cellular processes, including mainly …

The 14-3-3 proteins are a family of conserved regulatory molecules expressed in all
eukaryotic cells. A striking feature of the 14-3-3 proteins is their ability to bind a multitude of …

The Ras/Raf/MEK (mitogen-activated protein kinase/ERK kinase)/ERK (extracellular-signal-
regulated kinase) pathway is at the heart of signalling networks that govern proliferation …

The process by which extracellular signals are relayed from the plasma membrane to
specific intracellular sites is an essential facet of cellular regulation. Many signaling …

The ERK signaling cascade is a central MAPK pathway that plays a role in the regulation of
various cellular processes such as proliferation, differentiation, development, learning …

Signal transduction networks allow cells to perceive changes in the extracellular
environment and to mount an appropriate response. Mitogen-activated protein kinase …

This chapter includes a historic overview of 14-3-3 proteins with an emphasis on the
differences between potentially cancer-relevant isoforms on the genomic, protein and …

Summry—The Raf/MEK/ERK signaling was the first MAP kinase cascade to be
characterized. It is probably one of the most well known signal transduction pathways …

The extracellular signal-regulated kinase (ERK) cascade comprised of the Raf, MEK, and
ERK protein kinases constitutes a key effector cascade used by the Ras GTPases to relay …

▪ Abstract The mitogen-activated protein kinase (MAPK) group of serine/threonine protein
kinases mediates the response of cells to many extracellular stimuli such as cytokines and …