The vagus nerve and the inflammatory reflex—linking immunity and metabolism
The vagus nerve has an important role in regulation of metabolic homeostasis, and efferent
vagus nerve-mediated cholinergic signalling controls immune function and proinflammatory …
vagus nerve-mediated cholinergic signalling controls immune function and proinflammatory …
Second-generation antipsychotics and dysregulation of glucose metabolism: beyond weight gain
D Grajales, V Ferreira, ÁM Valverde - Cells, 2019 - mdpi.com
Second-generation antipsychotics (SGAs) are the cornerstone of treatment for schizophrenia
because of their high clinical efficacy. However, SGA treatment is associated with severe …
because of their high clinical efficacy. However, SGA treatment is associated with severe …
Pathophysiological mechanisms of increased cardiometabolic risk in people with schizophrenia and other severe mental illnesses
DC Henderson, B Vincenzi, NV Andrea… - The Lancet …, 2015 - thelancet.com
Patients with schizophrenia have increased mortality and morbidity compared with the
general population. These patients have a 20-year shorter lifespan than peers without …
general population. These patients have a 20-year shorter lifespan than peers without …
Antipsychotic drugs: from receptor-binding profiles to metabolic side effects
Background: Antipsychotic-induced metabolic side effects are major concerns in
psychopharmacology and clinical psychiatry. Their pathogenetic mechanisms are still not …
psychopharmacology and clinical psychiatry. Their pathogenetic mechanisms are still not …
Improved social interaction, recognition and working memory with cannabidiol treatment in a prenatal infection (poly I: C) rat model
Neuropsychiatric disorders such as schizophrenia are associated with cognitive impairment,
including learning, memory and attention deficits. Antipsychotic drugs are limited in their …
including learning, memory and attention deficits. Antipsychotic drugs are limited in their …
Inhibition of hypothalamic inflammation reverses diet-induced insulin resistance in the liver
M Milanski, AP Arruda, A Coope, LM Ignacio-Souza… - Diabetes, 2012 - Am Diabetes Assoc
Defective liver gluconeogenesis is the main mechanism leading to fasting hyperglycemia in
type 2 diabetes, and, in concert with steatosis, it is the hallmark of hepatic insulin resistance …
type 2 diabetes, and, in concert with steatosis, it is the hallmark of hepatic insulin resistance …
Gaussian accelerated molecular dynamics in NAMD
Gaussian accelerated molecular dynamics (GaMD) is a recently developed enhanced
sampling technique that provides efficient free energy calculations of biomolecules. Like the …
sampling technique that provides efficient free energy calculations of biomolecules. Like the …
Accelerated molecular dynamics simulations of ligand binding to a muscarinic G-protein-coupled receptor
Elucidating the detailed process of ligand binding to a receptor is pharmaceutically
important for identifying druggable binding sites. With the ability to provide atomistic detail …
important for identifying druggable binding sites. With the ability to provide atomistic detail …
Gaussian accelerated molecular dynamics: theory, implementation, and applications
Y Miao, JA McCammon - Annual reports in computational chemistry, 2017 - Elsevier
Abstract A novel Gaussian Accelerated Molecular Dynamics (GaMD) method has been
developed for simultaneous unconstrained enhanced sampling and free energy calculation …
developed for simultaneous unconstrained enhanced sampling and free energy calculation …
Understanding the effects of antipsychotics on appetite control
S Mukherjee, S Skrede, E Milbank… - Frontiers in …, 2022 - frontiersin.org
Antipsychotic drugs (APDs) represent a cornerstone in the treatment of schizophrenia and
other psychoses. The effectiveness of the first generation (typical) APDs are hampered by so …
other psychoses. The effectiveness of the first generation (typical) APDs are hampered by so …