Surfactant protein D in respiratory and non-respiratory diseases

GL Sorensen - Frontiers in medicine, 2018 - frontiersin.org
Surfactant protein D (SP-D) is a multimeric collectin that is involved in innate immune
defense and expressed in pulmonary, as well as non-pulmonary, epithelia. SP-D exerts …

The dual role of surfactant protein-D in vascular inflammation and development of cardiovascular disease

KB Colmorten, AB Nexoe, GL Sorensen - Frontiers in Immunology, 2019 - frontiersin.org
Cardiovascular disease (CVD) is responsible for 31% of all global deaths. Atherosclerosis is
the major cause of cardiovascular disease and is a chronic inflammatory disorder in the …

Genetic association of pulmonary surfactant protein genes, SFTPA1, SFTPA2, SFTPB, SFTPC, and SFTPD with cystic fibrosis

Z Lin, N Thorenoor, R Wu, SL DiAngelo, M Ye… - Frontiers in …, 2018 - frontiersin.org
Surfactant proteins (SP) are involved in surfactant function and innate immunity in the
human lung. Both lung function and innate immunity are altered in CF, and altered SP levels …

Increased expression of immune-related genes in leukocytes of patients with diagnosed gestational diabetes mellitus (GDM)

M Wojcik, A Zieleniak… - Experimental …, 2016 - journals.sagepub.com
Compelling evidence indicates that the immune system is linked to metabolism in
gestational diabetes mellitus (GDM), but factors participating in these processes still are …

Endurance exercise training decreased serum levels of surfactant protein D and improved aerobic fitness of obese women with type-2 diabetes

S Rezaei, MM Shamsi, M Mahdavi, A Jamali… - Diabetology & metabolic …, 2017 - Springer
Abstract Background Surfactant protein D (SP-D) is a member of the collectin family and is
an important component of the pulmonary innate host defense. To find the relationship …

Identification of candidate biomarkers and pathways associated with type 1 diabetes mellitus using bioinformatics analysis

M Pujar, B Vastrad, S Kavatagimath, C Vastrad… - Scientific Reports, 2022 - nature.com
Type 1 diabetes mellitus (T1DM) is a metabolic disorder for which the underlying molecular
mechanisms remain largely unclear. This investigation aimed to elucidate essential …

Odyssey of surfactant proteins SP-A and SP-D: innate immune surveillance molecules

U Kishore, R Bulla, T Madan - Frontiers in Immunology, 2020 - frontiersin.org
Surfactant protein A (SP-A) and D (SP-D) are hydrophilic collagenous C-type lectins, which
were originally discovered in the lungs associated with surfactant phospholipids. It was later …

Association between the surfactant protein D (SFTPD) gene and subclinical carotid artery atherosclerosis

GL Sorensen, EM Bladbjerg, R Steffensen, Q Tan… - Atherosclerosis, 2016 - Elsevier
Abstract Objective Surfactant protein D (SP-D) is a defense collectin with inflammation-
modulating properties. SP-D deficiency inhibits atherosclerosis in vivo, and the circulatory …

Biomarkers of lung injury in cardiothoracic surgery

GE Engels, W van Oeveren - Disease markers, 2015 - Wiley Online Library
Diagnosis of pulmonary dysfunction is currently almost entirely based on a vast series of
physiological changes, but comprehensive research is focused on determining biomarkers …

Association of surfactant protein D gene polymorphism with susceptibility to gestational diabetes mellitus: a case–control study

J Xu, Y Chen, L Tang, X Teng, L Feng, L Jin… - BMC Pregnancy and …, 2022 - Springer
Abstract Background Surfactant protein D (SP-D) is a critical component of the innate
immune system intrinsically linked to energy metabolism. However, the relationship of SP-D …