The microtubule-based spindle orchestrates chromosome segregation during cell division.
Following more than a century of study, many components and pathways contributing to …

Microtubules are cytoskeletal filaments essential for numerous aspects of cell physiology.
They are polarized polymeric tubes with a fast growing plus end and a slow growing minus …

Tau is an abundant microtubule-associated protein in neurons. Tau aggregation into
insoluble fibrils is a hallmark of Alzheimer's disease and other types of dementia, yet the …

During cell division, kinetochore microtubules (KMTs) provide a physical linkage between
the chromosomes and the rest of the spindle. KMTs in mammalian cells are organized into …

To build the spindle at mitosis, motors exert spatially regulated forces on microtubules. We
know that dynein pulls on mammalian spindle microtubule minus-ends, and this localized …

Microtubule organization has a crucial role in regulating cell architecture. The geometry of
microtubule arrays strongly depends on the distribution of sites responsible for microtubule …

Cytoskeletal networks of actin filaments and myosin motors drive many dynamic cell
processes. A key characteristic of these networks is their contractility. Despite intense …

Mixtures of filaments and molecular motors form active materials with diverse dynamical
behaviors that vary based on their constituents' molecular properties. To develop a …

Cytoskeletal networks are foundational examples of active matter and central to self-
organized structures in the cell. In vivo, these networks are active and densely crosslinked …

Anaphase chromosome movement is thought to be mediated by pulling forces generated by
end-on attachment of microtubules to the outer face of kinetochores. However, it has been …