Glutamate receptor ion channels: structure, regulation, and function
The mammalian ionotropic glutamate receptor family encodes 18 gene products that
coassemble to form ligand-gated ion channels containing an agonist recognition site, a …
coassemble to form ligand-gated ion channels containing an agonist recognition site, a …
Molecular basis of NMDA receptor functional diversity
P Paoletti - European Journal of Neuroscience, 2011 - Wiley Online Library
NMDA receptors (NMDARs) form glutamate‐gated ion channels widely expressed in the
central nervous system and highly permeable to calcium ions. NMDARs have always …
central nervous system and highly permeable to calcium ions. NMDARs have always …
NMDA receptors in the central nervous system
NMDA-type glutamate receptors are ligand-gated ion channels that mediate a major
component of excitatory neurotransmission in the central nervous system (CNS). They are …
component of excitatory neurotransmission in the central nervous system (CNS). They are …
Synaptic GluN2A-containing NMDA receptors: from physiology to pathological synaptic plasticity
L Franchini, N Carrano, M Di Luca… - International journal of …, 2020 - mdpi.com
N-Methyl-d-Aspartate Receptors (NMDARs) are ionotropic glutamate-gated receptors.
NMDARs are tetramers composed by several homologous subunits of GluN1-, GluN2-, or …
NMDARs are tetramers composed by several homologous subunits of GluN1-, GluN2-, or …
Molecular basis of positive allosteric modulation of GluN2B NMDA receptors by polyamines
NMDA receptors (NMDARs) form glutamate‐gated ion channels that have central roles in
neuronal communication and plasticity throughout the brain. Dysfunctions of NMDARs are …
neuronal communication and plasticity throughout the brain. Dysfunctions of NMDARs are …
An increase in synaptic NMDA receptors in the insular cortex contributes to neuropathic pain
S Qiu, T Chen, K Koga, Y Guo, H Xu, Q Song… - Science …, 2013 - science.org
Neurons in the insular cortex are activated by acute and chronic pain, and inhibition of
neuronal activity in the insular cortex has analgesic effects. We found that in a mouse model …
neuronal activity in the insular cortex has analgesic effects. We found that in a mouse model …
Glutamate receptor homologs in plants: functions and evolutionary origins
The plant glutamate-like receptor homologs (GLRs) are homologs of mammalian ionotropic
glutamate receptors (iGluRs) which were discovered more than 10 years ago, and are …
glutamate receptors (iGluRs) which were discovered more than 10 years ago, and are …
Control of assembly and function of glutamate receptors by the amino-terminal domain
The extracellular amino-terminal domains (ATDs) of the ionotropic glutamate receptor
subunits form a semiautonomous component of all glutamate receptors that resides distal to …
subunits form a semiautonomous component of all glutamate receptors that resides distal to …
Functions of intrinsic disorder in transmembrane proteins
M Kjaergaard, BB Kragelund - Cellular and Molecular Life Sciences, 2017 - Springer
Intrinsic disorder is common in integral membrane proteins, particularly in the intracellular
domains. Despite this observation, these domains are not always recognized as being …
domains. Despite this observation, these domains are not always recognized as being …
ER to synapse trafficking of NMDA receptors
M Horak, RS Petralia, M Kaniakova… - Frontiers in cellular …, 2014 - frontiersin.org
Glutamate is the major excitatory neurotransmitter in the mammalian central nervous system.
There are three distinct subtypes of ionotropic glutamate receptors (GluRs) that have been …
There are three distinct subtypes of ionotropic glutamate receptors (GluRs) that have been …