Surface functionalization strategies of extracellular vesicles

S Rayamajhi, S Aryal - Journal of Materials Chemistry B, 2020 - pubs.rsc.org
Extracellular vesicles (EVs) are lipid–protein bilayer vesicular constructs secreted to the
extracellular spaces by cells. All cells secrete EVs as a regular biological process that …

[HTML][HTML] Computer-aided nanodrug discovery: recent progress and future prospects

JJ Zheng, QZ Li, Z Wang, X Wang, Y Zhao… - Chemical Society …, 2024 - pubs.rsc.org
Nanodrugs, which utilise nanomaterials in disease prevention and therapy, have attracted
considerable interest since their initial conceptualisation in the 1990s. Substantial efforts …

Magnetic-based microfluidic device for on-chip isolation and detection of tumor-derived exosomes

H Xu, C Liao, P Zuo, Z Liu, BC Ye - Analytical chemistry, 2018 - ACS Publications
Exosomes are membrane-enclosed phospholipid extracellular vesicles, which can act as
mediators of intercellular communication. Although the original features endow tumor …

Surface modification of gold nanoparticles with neuron-targeted exosome for enhanced blood–brain barrier penetration

M Khongkow, T Yata, S Boonrungsiman… - Scientific reports, 2019 - nature.com
Gold nanoparticles (AuNPs) have been extensively used as nanomaterials for theranostic
applications due to their multifunctional characteristics in therapeutics, imaging, and surface …

Real time and label free profiling of clinically relevant exosomes

AAI Sina, R Vaidyanathan, S Dey, LG Carrascosa… - Scientific reports, 2016 - nature.com
Tumor-derived exosomes possess significant clinical relevance due to their unique
composition of genetic and protein material that is representative of the parent tumor …

Exosome as a vehicle for delivery of membrane protein therapeutics, PH20, for enhanced tumor penetration and antitumor efficacy

Y Hong, GH Nam, E Koh, S Jeon… - Advanced Functional …, 2018 - Wiley Online Library
As biochemical and functional studies of membrane protein remain a challenge, there is
growing interest in the application of nanotechnology to solve the difficulties of developing …

Emerging innovations on exosome-based onco-therapeutics

X Dai, Y Ye, F He - Frontiers in Immunology, 2022 - frontiersin.org
Exosomes, nano-sized extracellular vesicles for intercellular communications, are gaining
rapid momentum as a novel strategy for the diagnosis and therapeutics of a spectrum of …

Emerging biosensing platforms for quantitative detection of exosomes as diagnostic biomarkers

J Tan, Y Wen, M Li - Coordination Chemistry Reviews, 2021 - Elsevier
Exosomes are a class of extracellular vesicles secreted by all living cells. Exosomes carry
abundant constituents from their parental cells that are proteins, nucleic acids, lipids, small …

In vitro and in vivo models for evaluating the oral toxicity of nanomedicines

S Lama, O Merlin-Zhang, C Yang - Nanomaterials, 2020 - mdpi.com
Toxicity studies for conventional oral drug formulations are standardized and well
documented, as required by the guidelines of administrative agencies such as the US Food …

Strategies for engineering exosomes and their applications in drug delivery

M Zhu, S Li, S Li, H Wang, J Xu… - Journal of Biomedical …, 2021 - ingentaconnect.com
Exosomes are representative of a promising vehicle for delivery of biomolecules. Despite
their discovery nearly 40 years, knowledge of exosomes and extracellular vesicles (EVs) …