[HTML][HTML] Development, recent advances, and updates in binary, ternary co-amorphous systems, and ternary solid dispersions
A Saberi, M Kouhjani, D Yari, A Jahani… - Journal of Drug Delivery …, 2023 - Elsevier
Binary co-amorphous systems (CAMS) are a type of solid dispersion containing an active
pharmaceutical ingredient (API) and small molecule excipients. The properties of these …
pharmaceutical ingredient (API) and small molecule excipients. The properties of these …
Considerations for the selection of co-formers in the preparation of co-amorphous formulations
Co-amorphous drug delivery systems are evolving as a credible alternative to amorphous
solid dispersions technology. In Co-amorphous systems (CAMs), a drug is stabilized in …
solid dispersions technology. In Co-amorphous systems (CAMs), a drug is stabilized in …
Tranilast-matrine co-amorphous system: Strong intermolecular interactions, improved solubility, and physiochemical stability
D Hu, X Chen, D Li, H Zhang, Y Duan… - International Journal of …, 2023 - Elsevier
There is a great interest to develop co-amorphous drug delivery systems to enhance the
solubility of biopharmaceutics classification system (BCS) class II and IV drugs. However …
solubility of biopharmaceutics classification system (BCS) class II and IV drugs. However …
Ciprofloxacin-loaded zein/hyaluronic acid nanoparticles for ocular mucosa delivery
TA Jacinto, B Oliveira, SP Miguel, MP Ribeiro… - Pharmaceutics, 2022 - mdpi.com
Bacterial conjunctivitis is a worldwide problem that, if untreated, can lead to severe
complications, such as visual impairment and blindness. Topical administration of …
complications, such as visual impairment and blindness. Topical administration of …
Effects of additives on the physical stability and dissolution of polymeric amorphous solid dispersions: A review
Polymeric amorphous solid dispersion (ASD) is a popular approach for enhancing the
solubility of poorly water-soluble drugs. However, achieving both physical stability and …
solubility of poorly water-soluble drugs. However, achieving both physical stability and …
Current techniques of water solubility improvement for antioxidant compounds and their correlation with its activity: molecular pharmaceutics
The aqueous solubility of a drug is important in the oral formulation because the drug can be
absorbed from intestinal sites after being dissolved in the gastrointestinal fluid, leading to its …
absorbed from intestinal sites after being dissolved in the gastrointestinal fluid, leading to its …
Sinapic acid co-amorphous systems with amino acids for improved solubility and antioxidant activity
E Garbiec, N Rosiak, E Tykarska, P Zalewski… - International Journal of …, 2023 - mdpi.com
The objective of this study was to obtain co-amorphous systems of poorly soluble sinapic
acid using amino acids as co-formers. In order to assess the probability of the interaction of …
acid using amino acids as co-formers. In order to assess the probability of the interaction of …
Co-amorphous Drug Delivery Systems: a Review of Physical Stability, In Vitro and In Vivo Performance
Q Shi, Y Wang, SM Moinuddin, X Feng, F Ahsan - AAPS PharmSciTech, 2022 - Springer
Over the past few decades, co-amorphous solids have been used as a promising approach
for delivering poorly water-soluble drugs. Co-amorphous solids, comprising …
for delivering poorly water-soluble drugs. Co-amorphous solids, comprising …
Molecular complexes of drug combinations: a review of cocrystals, salts, coamorphous systems and amorphous solid dispersions
As the advancements in the medical technology and healthcare develop through the years,
combinational therapy has evolved to be an important treatment modality in many disease …
combinational therapy has evolved to be an important treatment modality in many disease …
Probing molecular packing of amorphous pharmaceutical solids using x-ray atomic pair distribution function and solid-state NMR
The structural investigation of amorphous pharmaceuticals is of paramount importance in
comprehending their physicochemical stability. However, it has remained a relatively …
comprehending their physicochemical stability. However, it has remained a relatively …