[HTML][HTML] Development, recent advances, and updates in binary, ternary co-amorphous systems, and ternary solid dispersions

A Saberi, M Kouhjani, D Yari, A Jahani… - Journal of Drug Delivery …, 2023 - Elsevier
Binary co-amorphous systems (CAMS) are a type of solid dispersion containing an active
pharmaceutical ingredient (API) and small molecule excipients. The properties of these …

Considerations for the selection of co-formers in the preparation of co-amorphous formulations

DL Yarlagadda, VSK Anand, AR Nair, KSN Sree… - International Journal of …, 2021 - Elsevier
Co-amorphous drug delivery systems are evolving as a credible alternative to amorphous
solid dispersions technology. In Co-amorphous systems (CAMs), a drug is stabilized in …

Tranilast-matrine co-amorphous system: Strong intermolecular interactions, improved solubility, and physiochemical stability

D Hu, X Chen, D Li, H Zhang, Y Duan… - International Journal of …, 2023 - Elsevier
There is a great interest to develop co-amorphous drug delivery systems to enhance the
solubility of biopharmaceutics classification system (BCS) class II and IV drugs. However …

Ciprofloxacin-loaded zein/hyaluronic acid nanoparticles for ocular mucosa delivery

TA Jacinto, B Oliveira, SP Miguel, MP Ribeiro… - Pharmaceutics, 2022 - mdpi.com
Bacterial conjunctivitis is a worldwide problem that, if untreated, can lead to severe
complications, such as visual impairment and blindness. Topical administration of …

Effects of additives on the physical stability and dissolution of polymeric amorphous solid dispersions: A review

J Li, Y Wang, D Yu - AAPS PharmSciTech, 2023 - Springer
Polymeric amorphous solid dispersion (ASD) is a popular approach for enhancing the
solubility of poorly water-soluble drugs. However, achieving both physical stability and …

Current techniques of water solubility improvement for antioxidant compounds and their correlation with its activity: molecular pharmaceutics

A Budiman, A Rusdin, DL Aulifa - Antioxidants, 2023 - mdpi.com
The aqueous solubility of a drug is important in the oral formulation because the drug can be
absorbed from intestinal sites after being dissolved in the gastrointestinal fluid, leading to its …

Sinapic acid co-amorphous systems with amino acids for improved solubility and antioxidant activity

E Garbiec, N Rosiak, E Tykarska, P Zalewski… - International Journal of …, 2023 - mdpi.com
The objective of this study was to obtain co-amorphous systems of poorly soluble sinapic
acid using amino acids as co-formers. In order to assess the probability of the interaction of …

Co-amorphous Drug Delivery Systems: a Review of Physical Stability, In Vitro and In Vivo Performance

Q Shi, Y Wang, SM Moinuddin, X Feng, F Ahsan - AAPS PharmSciTech, 2022 - Springer
Over the past few decades, co-amorphous solids have been used as a promising approach
for delivering poorly water-soluble drugs. Co-amorphous solids, comprising …

Molecular complexes of drug combinations: a review of cocrystals, salts, coamorphous systems and amorphous solid dispersions

J Li, X Wang, D Yu, Y Zhoujin, K Wang - International Journal of …, 2023 - Elsevier
As the advancements in the medical technology and healthcare develop through the years,
combinational therapy has evolved to be an important treatment modality in many disease …

Probing molecular packing of amorphous pharmaceutical solids using x-ray atomic pair distribution function and solid-state NMR

Z Chen, H Nie, CJ Benmore, PA Smith… - Molecular …, 2023 - ACS Publications
The structural investigation of amorphous pharmaceuticals is of paramount importance in
comprehending their physicochemical stability. However, it has remained a relatively …