Protein recruitment to DNA break sites is an integral part of the DNA damage response
(DDR). Elucidation of the hierarchy and temporal order with which DNA damage sensors as …

The repair of DNA double‑strand breaks (DSBs) is crucial for the preservation of genomic
integrity and the maintenance of cellular homeostasis. Non‑homologous DNA end joining …

The chemical synthesis of homogeneously modified histones is a powerful approach to
quantitatively decipher how post-translational modifications (PTMs) modulate epigenetic …

DNA double-strand breaks (DSBs) are repaired at DSB sites. How DSB sites assemble and
how broken DNA is prevented from separating is not understood. Here we uncover that the …

Telomeres are nanoscale DNA–protein complexes to protect and stabilize chromosomes.
The reexpression of telomerase in cancer cells is a key determinant crucial for the infinite …

Double-strand breaks (DSBs) are toxic lesions that can be generated by exposure to
genotoxic agents or during physiological processes, such as during V (D) J recombination …

Condensates are biomolecular assemblies that concentrate biomolecules without the help
of membranes. They are morphologically highly versatile and may emerge via distinct …

Cells have evolved an arsenal of molecular mechanisms to respond to continuous
alterations in the primary structure of DNA. At the cellular level, DNA damage response …

Although axonal damage induces rapid changes in gene expression in primary sensory
neurons, it remains unclear how this process is initiated. The transcription factor ATF3, one …

Background Dynamic chromatin remodeling is associated with changes in the epigenetic
pattern of histone acetylations and methylations required for processes based on dynamic …