Microorganisms in most ecological niches are constantly exposed to variations of many
environmental factors, including temperature; oxygen, nutrient, and water availability; …

Abstract EcoCyc (http://EcoCyc. org) is a model organism database built on the genome
sequence of Escherichia coli K-12 MG1655. Expert manual curation of the functions of …

Large-scale mining and analysis of bacterial datasets contribute to the comprehensive
characterization of complex microbial dynamics within a microbiome and among different …

The escalating amount of genome-scale data demands a pragmatic stance from the
research community. How can we utilize this deluge of information to better understand …

Nitrogen signalling in cyanobacteria involves a complex network in which the availability of
iron plays an important role. In the nitrogen-fixing cyanobacterium Anabaena sp. PCC 7120 …

In the filamentous cyanobacterium Anabaena sp. PCC 7120, the ferric uptake regulator FurA
functions as a global transcriptional regulator. Despite several analyses have focused on …

Advances in sequencing technology are resulting in the rapid emergence of large numbers
of complete genome sequences. High-throughput annotation and metabolic modeling of …

We present a new algorithm, BOBRO, for prediction of cis-regulatory motifs in a given set of
promoter sequences. The algorithm substantially improves the prediction accuracy and …

Abstract The National Center for Biotechnology Information (NCBI) recently announced
'1000 prokaryotic genomes are now completed and available in the Genome database'. The …

Background The goal of most programs developed to find transcription factor binding sites
(TFBSs) is the identification of discrete sequence motifs that are significantly over …