Flowing blood generates a frictional force called shear stress that has major effects on
vascular function. Branches and bends of arteries are exposed to complex blood flow …

Although the clinical demand for bioengineered blood vessels continues to rise, current
options for vascular conduits remain limited. The synergistic combination of emerging …

The mechanisms by which physical forces regulate endothelial cells to determine the
complexities of vascular structure and function are enigmatic,,,,. Studies of sensory neurons …

Mechanosensation is perhaps the last sensory modality not understood at the molecular
level. Ion channels that sense mechanical force are postulated to play critical roles in a …

Signalling from the extracellular matrix (ECM) is a fundamental cellular input that sustains
proliferation, opposes cell death and regulates differentiation. Through integrins, cells …

Mechanical forces are fundamental in cardiovascular biology, and deciphering the
mechanisms by which they act remains a testing frontier in cardiovascular research. Here …

Cellular responses to mechanical forces are crucial in embryonic development and adult
physiology, and are involved in numerous diseases, including atherosclerosis …

Establishment of a functional vascular network is rate-limiting in embryonic development,
tissue repair and engineering. During blood vessel formation, newly generated endothelial …

Endothelial cells (ECs) line the inside of blood vessels and respond to mechanical cues
generated by blood flow. Mechanical stimuli regulate the localization of YAP by reorganizing …

The field of angiogenesis research has primarily focused on the mechanisms of sprouting
angiogenesis. Yet vascular networks formed by vessel sprouting subsequently undergo …