Tumor suppressor genes cooperate with each other in tumors. Three important tumor
suppressor proteins, retinoblastoma (Rb), p53, phosphatase, and tensin homolog deleted …

Ubiquitin signaling is a conserved, widespread, and dynamic process in which protein
substrates are rapidly modified by ubiquitin to impact protein activity, localization, or stability …

Transforming growth factor β (TGF-β) and structurally related factors use several intracellular
signaling pathways in addition to Smad signaling to regulate a wide array of cellular …

Post-translational modification (PTM) in histone proteins is a covalent modification which
mainly consists of methylation, phosphorylation, acetylation, ubiquitylation, SUMOylation …

Ubiquitination has long been recognised as a key determinator of protein fate by tagging
proteins for proteasomal degradation. Most recently, the ability of conjugated ubiquitin …

Clinical evidence suggests that poor persistence of chimeric antigen receptor-T cells (CAR-
T) in patients limits therapeutic efficacy. Here, we designed a CAR with recyclable capability …

Ubiquitin acts as a versatile cellular signal that controls a wide range of biological processes
including protein degradation, DNA repair, endocytosis, autophagy, transcription, immunity …

Transforming growth factor-β utilizes a multitude of intracellular signaling pathways in
addition to Smads to regulate a wide array of cellular functions. These non-canonical, non …

Retinoic-acid-inducible gene-I (RIG-I; also called DDX58) is a cytosolic viral RNA receptor
that interacts with MAVS (also called VISA, IPS-1 or Cardif) to induce type I interferon …

Transforming growth factor‐β (TGF‐β) is a proinflammatory cytokine known to control a
diverse array of pathological and physiological conditions during normal development and …