Physicians, policymakers, and researchers are increasingly focused on finding ways to
decrease opioid use and overdose in the United States both of which have sharply …

Abstract Purpose of Review The opioid crisis most likely is the most profound public health
crisis our nation has faced. In 2015 alone, 52,000 people died of drug overdoses, with over …

Background: Prescription opioid–related overdose deaths increased sharply during 1999–
2010 in the United States in parallel with increased opioid prescribing. CDC assessed …

Objectives. To estimate health outcomes of policies to mitigate the opioid epidemic.
Methods. We used dynamic compartmental modeling of US adults, in various pain, opioid …

Back pain affects most adults, causes disability for some, and is a common reason for
seeking healthcare. In the United States, opioid prescription for low back pain has …

Background: Expert guidelines recommend reducing or discontinuing long-term opioid
therapy (LTOT) when risks outweigh benefits, but evidence on the effect of dose reduction …

The purpose of this comprehensive review is to describe various aspects of crisis of opioid
use in the United States. The obstacles that must be surmounted are primarily inappropriate …

Objective: Increasing rates of opioid use disorders (OUDs)(abuse and dependence) among
patients prescribed opioids are a significant public health concern. We investigated the …

The relationships between the initial opioid prescription characteristics and pain etiology
with the probability of opioid discontinuation were explored in this retrospective cohort study …

Prescription opioid abuse and addiction, along with consequences such as overdose death
and increasing transition to heroin use, constitute a devastating public health problem in the …