The role of vascular smooth muscle cells in the development of aortic aneurysms and dissections
KB Rombouts, TAR van Merrienboer… - European journal of …, 2022 - Wiley Online Library
Background Aortic aneurysms (AA) are pathological dilations of the aorta, associated with
an overall mortality rate up to 90% in case of rupture. In addition to dilation, the aortic layers …
an overall mortality rate up to 90% in case of rupture. In addition to dilation, the aortic layers …
[HTML][HTML] The mechanism and therapy of aortic aneurysms
Aortic aneurysm is a chronic aortic disease affected by many factors. Although it is generally
asymptomatic, it poses a significant threat to human life due to a high risk of rupture …
asymptomatic, it poses a significant threat to human life due to a high risk of rupture …
[HTML][HTML] Tissue engineering and regenerative medicine: achievements, future, and sustainability in Asia
F Han, J Wang, L Ding, Y Hu, W Li, Z Yuan… - … in bioengineering and …, 2020 - frontiersin.org
Exploring innovative solutions to improve the healthcare of the aging and diseased
population continues to be a global challenge. Among a number of strategies toward this …
population continues to be a global challenge. Among a number of strategies toward this …
Role of vascular smooth muscle cell phenotypic switching and calcification in aortic aneurysm formation: involvement of vitamin K-dependent processes
P Petsophonsakul, M Furmanik, R Forsythe… - … , and vascular biology, 2019 - Am Heart Assoc
Aortic aneurysm is a vascular disease whereby the ECM (extracellular matrix) of a blood
vessel degenerates, leading to dilation and eventually vessel wall rupture. Recently, it was …
vessel degenerates, leading to dilation and eventually vessel wall rupture. Recently, it was …
[HTML][HTML] Aortic aneurysms: current pathogenesis and therapeutic targets
MJ Cho, MR Lee, JG Park - Experimental & Molecular Medicine, 2023 - nature.com
Aortic aneurysm is a chronic disease characterized by localized expansion of the aorta,
including the ascending aorta, arch, descending aorta, and abdominal aorta. Although aortic …
including the ascending aorta, arch, descending aorta, and abdominal aorta. Although aortic …
[HTML][HTML] Macrophage-derived mir-155-containing exosomes suppress fibroblast proliferation and promote fibroblast inflammation during cardiac injury
C Wang, C Zhang, L Liu, A Xi, B Chen, Y Li, J Du - Molecular Therapy, 2017 - cell.com
Inflammation plays an important role in cardiac injuries. Here, we examined the role of
miRNA in regulating inflammation and cardiac injury during myocardial infarction. We …
miRNA in regulating inflammation and cardiac injury during myocardial infarction. We …
Diabetes and aortic aneurysm: current state of the art
Aortic aneurysm is a life-threatening disease due to the risk of aortic rupture. The only
curative treatment available relies on surgical approaches; drug-based therapies are …
curative treatment available relies on surgical approaches; drug-based therapies are …
LOX Mutations Predispose to Thoracic Aortic Aneurysms and Dissections
D Guo, ES Regalado, L Gong, X Duan… - Circulation …, 2016 - Am Heart Assoc
Rationale: Mutations in several genes have been identified that are responsible for 25% of
families with familial thoracic aortic aneurysms and dissections. However, the causative …
families with familial thoracic aortic aneurysms and dissections. However, the causative …
[HTML][HTML] Single-cell RNA sequencing identifies an Il1rn+/Trem1+ macrophage subpopulation as a cellular target for mitigating the progression of thoracic aortic …
X Liu, W Chen, G Zhu, H Yang, W Li, M Luo, C Shu… - Cell discovery, 2022 - nature.com
Thoracic aortic aneurysm and dissection (TAAD) is a life-threatening condition characterized
by medial layer degeneration of the thoracic aorta. A thorough understanding of the …
by medial layer degeneration of the thoracic aorta. A thorough understanding of the …
Matrix mechanotransduction mediated by thrombospondin-1/integrin/YAP in the vascular remodeling
Y Yamashiro, BQ Thang, K Ramirez… - Proceedings of the …, 2020 - National Acad Sciences
The extracellular matrix (ECM) initiates mechanical cues that activate intracellular signaling
through matrix–cell interactions. In blood vessels, additional mechanical cues derived from …
through matrix–cell interactions. In blood vessels, additional mechanical cues derived from …