Upon receipt in the dorsal horn (DH) of the spinal cord, nociceptive (pain-signalling)
information from the viscera, skin and other organs is subject to extensive processing by a …

Systemic administration of analgesics can lead to serious adverse side effects
compromising therapeutic benefit in some patients. Information coding pain transmits along …

Gonadal hormones not only play a pivotal role in reproductive behavior and sexual
differentiation, they also contribute to thermoregulation, feeding, memory, neuronal survival …

Much research has been undertaken in the field of pain in an attempt to find an effective
treatment. Insights into the underlying mechanisms of pain have been gained from studies …

Pain treatment with centrally acting opiates is limited by tolerance. Tolerance is a decreasing
effect of a drug with prolonged administration of that drug or of a related (eg, endogenous) …

Endogenous opiate peptides acting pre-and post-synaptically in the dorsal horn of spinal
cord inhibit transmission of nociceptive stimuli. We transfected neurons of the dorsal root …

A limitation of current gene therapy efforts aimed at central nervous system disorders
concerns distribution of vectors on direct injection into neural tissue. Here we have …

Background Chromaffin cells from the adrenal gland secrete a mixture of compounds that
have a strong analgesic effect, especially when administered intrathecally. Many studies in …

We have set out to establish a fast, simple and innocuous method for repeatedly obtaining
cerebrospinal fluid (CSF) samples from rats that are undergoing different experimental …

The use of cell lines utilized as biologic “minipumps” to provide antinociceptive molecules,
such as GABA, in animal models of pain is a newly developing area in transplantation …