A functional perspective on phenotypic heterogeneity in microorganisms

M Ackermann - Nature Reviews Microbiology, 2015 - nature.com
Most microbial communities consist of a genetically diverse assembly of different organisms,
and the level of genetic diversity plays an important part in community properties and …

Stochastic developmental variation, an epigenetic source of phenotypic diversity with far-reaching biological consequences

G Vogt - Journal of Biosciences, 2015 - Springer
This article reviews the production of different phenotypes from the same genotype in the
same environment by stochastic cellular events, nonlinear mechanisms during patterning …

Reduced phenotypic plasticity evolves in less predictable environments

C Leung, M Rescan, D Grulois, LM Chevin - Ecology letters, 2020 - Wiley Online Library
Phenotypic plasticity is a prominent mechanism for coping with variable environments, and a
key determinant of extinction risk. Evolutionary theory predicts that phenotypic plasticity …

Gene loss and compensatory evolution promotes the emergence of morphological novelties in budding yeast

Z Farkas, K Kovács, Z Sarkadi, D Kalapis… - Nature Ecology & …, 2022 - nature.com
Deleterious mutations are generally considered to be irrelevant for morphological evolution.
However, they could be compensated by conditionally beneficial mutations, thereby …

Plant-derived antifungal agent poacic acid targets β-1, 3-glucan

JS Piotrowski, H Okada, F Lu, SC Li… - Proceedings of the …, 2015 - National Acad Sciences
A rise in resistance to current antifungals necessitates strategies to identify alternative
sources of effective fungicides. We report the discovery of poacic acid, a potent antifungal …

Using phenotypic plasticity to understand the structure and evolution of the genotype–phenotype map

LM Chevin, C Leung, A Le Rouzic, T Uller - Genetica, 2022 - Springer
Deciphering the genotype–phenotype map necessitates relating variation at the genetic
level to variation at the phenotypic level. This endeavour is inherently limited by the …

[HTML][HTML] Phenotypic heterogeneity in fungi: importance and methodology

SK Hewitt, DS Foster, PS Dyer, SV Avery - Fungal Biology Reviews, 2016 - Elsevier
Phenotypic heterogeneity describes the variation that exists between individual cells, spores
or other biological entities within genetically-uniform populations of fungi or other organisms …

Role of genetic architecture in phenotypic plasticity

P Kovuri, A Yadav, H Sinha - Trends in Genetics, 2023 - cell.com
Phenotypic plasticity, the ability of an organism to display different phenotypes across
environments, is widespread in nature. Plasticity aids survival in novel environments …

Genome editing to generate sake yeast strains with eight mutations that confer excellent brewing characteristics

T Chadani, S Ohnuki, A Isogai, T Goshima, M Kashima… - Cells, 2021 - mdpi.com
Sake yeast is mostly diploid, so the introduction of recessive mutations to improve brewing
characteristics requires considerable effort. To construct sake yeast with multiple excellent …

Cucurbitacin B exerts antiaging effects in yeast by regulating autophagy and oxidative stress

Y Lin, Y Kotakeyama, J Li, Y Pan… - Oxidative Medicine …, 2019 - Wiley Online Library
The budding yeast Saccharomyces cerevisiae has been used as a model organism for the
basic mechanism of aging, which provides useful assay systems for measuring both …