A review of the potential protective effects of pentoxifylline against drug-induced nephrotoxicity
Purpose Drug-induced nephrotoxicity is one of the most common side effects of medications
and accounts for about 20% of hospital admissions for acute kidney injury (AKI). Some …
and accounts for about 20% of hospital admissions for acute kidney injury (AKI). Some …
Effects of pentoxifylline and alpha lipoic acid on methotrexate-induced damage in liver and kidney of rats
The aim of the current study was to investigate the probable protective effects of
Pentoxifylline (PTX) and Alpha Lipoic Acid (ALA), which display anti-oxidative efficacy …
Pentoxifylline (PTX) and Alpha Lipoic Acid (ALA), which display anti-oxidative efficacy …
Anti-inflammatory effects of vinpocetine on the functional expression of nuclear factor-kappa B and tumor necrosis factor-alpha in a rat model of cerebral ischemia …
H Wang, K Zhang, L Zhao, J Tang, L Gao, Z Wei - Neuroscience letters, 2014 - Elsevier
Objective The restoration of blood flow to the brain after ischemic stroke prevents further,
extensive damage but can result in reperfusion injury. The inflammation response is one of …
extensive damage but can result in reperfusion injury. The inflammation response is one of …
Phosphodiesterase (1, 3 & 5) inhibitors attenuate diclofenac-induced acute kidney toxicity in rats
Diclofenac, one of the most commonly used non-steroidal anti-inflammatory drugs, leads to
severe adverse effects on the kidneys. The aim of the present study was to investigate the …
severe adverse effects on the kidneys. The aim of the present study was to investigate the …
Thymoquinone ameliorates amikacin induced oxidative damage in rat brain tissue
We investigated the potential neuroprotective effects of thymoquinone (TQ) on amikacin (AK)
induced oxidative damage in rat brain. We used 21 male rats divided randomly into three …
induced oxidative damage in rat brain. We used 21 male rats divided randomly into three …
The nephroprotective properties of taurine-amikacin treatment in rats are mediated through HSP25 and TLR-4 regulation
N Madbouly, A Azmy, A Salama, A El-Amir - The Journal of Antibiotics, 2021 - nature.com
Amikacin (AMK) is one of the most effective aminoglycoside antibiotics. However,
nephrotoxicity is a major deleterious and dose-limiting side effect associated with its clinical …
nephrotoxicity is a major deleterious and dose-limiting side effect associated with its clinical …
Thymoquinone protection from amikacin induced renal injury in rats
We investigated whether thymoquinone (TQ) exerts a beneficial effect on renal injury due to
amikacin (AK) administration in rats. To generate kidney damage with AK, a single 1.2 g/kg …
amikacin (AK) administration in rats. To generate kidney damage with AK, a single 1.2 g/kg …
Antioxidative and Anti‐Inflammatory Protective Effects of β‐Caryophyllene against Amikacin‐Induced Nephrotoxicity in Rat by Regulating the Nrf2/AMPK/AKT and NF‐κB/TGF …
BS Rajab, TA Albukhari, AA Khan… - Oxidative Medicine …, 2022 - Wiley Online Library
Herein, the molecular pathogenic pathways implicated in renal injury triggered by amikacin
(AK), together with the alleviating actions of β‐caryophyllene (BCP), were investigated. Adult …
(AK), together with the alleviating actions of β‐caryophyllene (BCP), were investigated. Adult …
Prevention of nephrotoxicity induced by amikacin: The role of misoprostol, A prostaglandin E1 analogue
S Azırak - Prostaglandins & Other Lipid Mediators, 2023 - Elsevier
Amikacin (AK) is an aminoglycoside that is widely used to treat life-threatening Gram-
negative infections, especially in intensive care units. Despite its wide clinical indications …
negative infections, especially in intensive care units. Despite its wide clinical indications …
Effect of pentoxifylline on kidney damage induced by nitrosamine in male rats
C Jalili, D Moradi, S Roshankhah… - Research in …, 2019 - journals.lww.com
Nitrosamines are well-known carcinogenic agents. Humans are exposed to nitrosamines in
various ways, the most important of which is the diet. Pentoxifylline is a xanthine derivative …
various ways, the most important of which is the diet. Pentoxifylline is a xanthine derivative …