Next generation sequencing (NGS) has been an invaluable tool to put genomic sequencing
into clinical practice. The incorporation of clinically relevant target sequences into NGS …

Approximately 1 in 2 Japanese people are estimated to be diagnosed with cancer during
their lifetime. Cancer still remains the leading cause of death in Japan, therefore the …

Next‐generation sequencing (NGS) of tumor tissue (ie, clinical sequencing) can guide
clinical management by providing information about actionable gene aberrations that have …

Background Implementation of personalized medicine requires the accessibility of tumor
molecular profiling in order to allow prioritization of appropriate targeted therapies for …

Background To promote precision oncology in clinical practice, the Japanese Society of
Medical Oncology, the Japanese Society of Clinical Oncology, and the Japanese Cancer …

IMPORTANCE Precision oncology using comprehensive genomic profiling (CGP) by next-
generation sequencing is aimed at companion diagnosis and genomic profiling. The clinical …

Although precision oncology is transforming clinical management of patients with cancer,
many hospitals face challenges to effectively implement precision oncology. In addition, the …

Objectives We aimed to examine the association between homologous recombination repair
(HRR)-related gene mutations and efficacy of oxaliplatin-based chemotherapy in patients …

Induced pluripotent stem cells (iPSC)-based therapies have been hailed as the future of
regenerative medicine because of their potential to provide treatment options for most …

Abstract Background Since June 2019, cancer genomic profiling (CGP) tests have been
reimbursed by the National Health Insurance system in Japan, with restrictions for …